Zinc in PDB 5of9: Crystal Structure of Human MORC2 (Residues 1-603)

The structure of Crystal Structure of Human MORC2 (Residues 1-603), PDB code: 5of9 was solved by C.H.Douse, M.Shamin, Y.Modis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	64.91 / 1.81
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	66.170, 127.930, 80.190, 90.00, 101.22, 90.00
R / Rfree (%)	16.1 / 18.8

The structure of Crystal Structure of Human MORC2 (Residues 1-603) also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of Human MORC2 (Residues 1-603) (pdb code 5of9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human MORC2 (Residues 1-603), PDB code: 5of9:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human MORC2 (Residues 1-603)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human MORC2 (Residues 1-603) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn701 b:35.8 occ:1.00 SG A:CYS536 2.3 37.8 1.0 SG A:CYS525 2.3 35.0 1.0 SG A:CYS502 2.3 35.6 1.0 SG A:CYS499 2.4 34.9 1.0 HA A:CYS536 2.8 48.1 1.0 HB3 A:CYS502 3.0 42.9 1.0 HB2 A:CYS525 3.0 43.0 1.0 HB3 A:CYS499 3.0 35.2 1.0 H A:CYS525 3.0 45.7 1.0 HB2 A:CYS499 3.0 35.2 1.0 CB A:CYS499 3.0 29.4 1.0 CB A:CYS536 3.1 55.1 1.0 HB3 A:CYS536 3.1 66.2 1.0 H A:CYS502 3.2 46.8 1.0 CB A:CYS502 3.3 35.7 1.0 CB A:CYS525 3.3 35.8 1.0 CA A:CYS536 3.4 40.0 1.0 HB2 A:LEU501 3.8 41.6 1.0 N A:CYS525 3.8 38.1 1.0 N A:CYS502 3.8 39.0 1.0 HB2 A:CYS536 4.0 66.2 1.0 HB3 A:CYS525 4.0 43.0 1.0 HB2 A:CYS502 4.0 42.9 1.0 CA A:CYS502 4.1 34.6 1.0 CA A:CYS525 4.2 45.6 1.0 N A:CYS536 4.2 42.6 1.0 HH21 A:ARG506 4.2 49.6 1.0 HB2 A:LYS504 4.3 40.6 1.0 H A:CYS536 4.4 51.1 1.0 H A:LEU501 4.4 42.3 1.0 H A:LYS504 4.5 37.2 1.0 CA A:CYS499 4.5 36.5 1.0 HA A:CYS525 4.6 54.8 1.0 HE A:ARG506 4.6 41.8 1.0 HA A:VAL524 4.6 48.9 1.0 HB A:VAL524 4.6 45.4 1.0 O A:HOH1058 4.6 36.9 1.0 C A:CYS536 4.6 36.5 1.0 H A:LEU503 4.7 36.8 1.0 CB A:LEU501 4.7 34.7 1.0 O A:CYS536 4.7 34.9 1.0 HD2 A:LYS504 4.8 45.9 1.0 C A:CYS502 4.8 30.6 1.0 HA A:CYS499 4.9 43.9 1.0 C A:LEU501 4.9 37.6 1.0 HA A:CYS502 4.9 41.6 1.0 HD12 A:LEU501 4.9 58.6 1.0 C A:VAL524 5.0 40.9 1.0 HB3 A:LEU501 5.0 41.6 1.0 N A:LEU503 5.0 30.6 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human MORC2 (Residues 1-603)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human MORC2 (Residues 1-603) within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn701 b:50.5 occ:1.00 SG B:CYS502 2.3 64.2 1.0 SG B:CYS525 2.3 61.5 1.0 SG B:CYS499 2.4 57.7 1.0 SG B:CYS536 2.4 65.1 1.0 HB3 B:CYS499 2.8 66.2 1.0 HA B:CYS536 2.8 80.3 1.0 CB B:CYS499 2.9 55.3 1.0 HB2 B:CYS499 2.9 66.2 1.0 H B:CYS502 3.0 67.1 1.0 HB3 B:CYS536 3.1 79.2 1.0 CB B:CYS536 3.2 66.1 1.0 HB2 B:CYS525 3.2 77.6 1.0 H B:CYS525 3.2 75.0 1.0 CB B:CYS525 3.4 64.8 1.0 HB3 B:CYS502 3.5 81.3 1.0 CA B:CYS536 3.5 67.0 1.0 CB B:CYS502 3.5 67.8 1.0 HB2 B:LEU501 3.6 71.4 1.0 N B:CYS502 3.7 56.0 1.0 N B:CYS525 3.9 62.6 1.0 HB2 B:CYS536 4.1 79.2 1.0 HB3 B:CYS525 4.1 77.6 1.0 CA B:CYS502 4.2 56.0 1.0 HH21 B:ARG506 4.3 0.1 1.0 CA B:CYS525 4.3 64.2 1.0 HB2 B:CYS502 4.3 81.3 1.0 H B:LEU501 4.3 65.8 1.0 N B:CYS536 4.3 70.2 1.0 CA B:CYS499 4.4 53.1 1.0 HB2 B:LYS504 4.4 65.1 1.0 CB B:LEU501 4.5 59.6 1.0 H B:LYS504 4.5 61.5 1.0 O B:CYS536 4.6 78.9 1.0 HB B:VAL524 4.6 74.2 1.0 C B:CYS536 4.6 67.7 1.0 H B:CYS536 4.6 84.0 1.0 HA B:CYS525 4.7 76.9 1.0 HE B:ARG506 4.7 92.6 1.0 HB3 B:LEU501 4.7 71.4 1.0 HA B:VAL524 4.7 72.1 1.0 HA B:CYS499 4.7 63.5 1.0 HD12 B:LEU501 4.8 77.1 1.0 C B:LEU501 4.8 61.2 1.0 H B:LEU503 4.8 61.8 1.0 HD2 B:LYS504 4.8 82.8 1.0 C B:CYS499 4.9 55.0 1.0 N B:LEU501 4.9 55.0 1.0 C B:CYS502 5.0 53.4 1.0 NH2 B:ARG506 5.0 92.6 1.0 CA B:LEU501 5.0 56.5 1.0 HA B:CYS502 5.0 67.0 1.0

C.H.Douse, S.Bloor, Y.Liu, M.Shamin, I.A.Tchasovnikarova, R.T.Timms, P.J.Lehner, Y.Modis. Neuropathic MORC2 Mutations Perturb Ghkl Atpase Dimerization Dynamics and Epigenetic Silencing By Multiple Structural Mechanisms. Nat Commun V. 9 651 2018.
ISSN: ESSN 2041-1723
PubMed: 29440755
DOI: 10.1038/S41467-018-03045-X