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Zinc in PDB 5mwm: Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with IP6

Enzymatic activity of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with IP6

All present enzymatic activity of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with IP6:
2.7.1.158;

Protein crystallography data

The structure of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with IP6, PDB code: 5mwm was solved by E.Franco-Echevarria, J.Sanz-Aparicio, B.Gonzalez, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 57.46 / 2.60
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 60.550, 71.637, 61.822, 90.00, 111.66, 90.00
R / Rfree (%) 25.3 / 29

Zinc Binding Sites:

The binding sites of Zinc atom in the Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with IP6 (pdb code 5mwm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with IP6, PDB code: 5mwm:

Zinc binding site 1 out of 1 in 5mwm

Go back to Zinc Binding Sites List in 5mwm
Zinc binding site 1 out of 1 in the Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with IP6


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase From M. Musculus in Complex with IP6 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn502

b:46.9
occ:1.00
SG A:CYS181 2.2 42.1 1.0
SG A:CYS159 2.2 57.5 1.0
SG A:CYS162 2.4 46.5 1.0
SG A:CYS291 2.7 68.7 1.0
CB A:CYS181 3.1 42.6 1.0
CB A:CYS291 3.2 70.6 1.0
CB A:CYS162 3.3 47.0 1.0
CB A:CYS159 3.5 54.3 1.0
CA A:CYS181 3.8 40.9 1.0
N A:CYS159 4.1 55.2 1.0
CD A:PRO182 4.3 38.2 1.0
CA A:CYS159 4.4 53.6 1.0
N A:CYS162 4.4 46.9 1.0
CA A:CYS162 4.5 47.1 1.0
C A:CYS181 4.6 39.5 1.0
N A:SER294 4.6 62.9 1.0
N A:PRO182 4.7 37.6 1.0
CA A:CYS291 4.7 72.9 1.0
CB A:ALA293 4.8 65.2 1.0
CG1 A:VAL158 4.9 56.3 1.0
CB A:SER294 4.9 61.1 1.0
O A:CYS159 4.9 52.2 1.0
C A:CYS159 5.0 52.2 1.0

Reference:

E.Franco-Echevarria, J.Sanz-Aparicio, C.A.Brearley, J.M.Gonzalez-Rubio, B.Gonzalez. The Crystal Structure of Mammalian Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Reveals A New Zinc-Binding Site and Key Features For Protein Function. J. Biol. Chem. V. 292 10534 2017.
ISSN: ESSN 1083-351X
PubMed: 28450399
DOI: 10.1074/JBC.M117.780395
Page generated: Wed Dec 16 06:33:53 2020

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