Atomistry » Zinc » PDB 5lrm-5lyf » 5lxq
Atomistry »
  Zinc »
    PDB 5lrm-5lyf »
      5lxq »

Zinc in PDB 5lxq: Structure of Prl-1 in Complex with the Bateman Domain of CNNM2

Enzymatic activity of Structure of Prl-1 in Complex with the Bateman Domain of CNNM2

All present enzymatic activity of Structure of Prl-1 in Complex with the Bateman Domain of CNNM2:
3.1.3.48;

Protein crystallography data

The structure of Structure of Prl-1 in Complex with the Bateman Domain of CNNM2, PDB code: 5lxq was solved by P.Gimenez-Mascarell, I.Oyenarte, S.Hardy, T.Breiderhoff, M.Stuiver, E.Kostantin, T.Diercks, A.L.Pey, J.Ereno-Orbea, M.L.Martinez-Chantar, R.Khalaf-Nazzal, F.Claverie-Martin, D.Muller, M.Tremblay, L.A.Martinez-Cruz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.88 / 3.34
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 166.930, 125.560, 61.040, 90.00, 111.43, 90.00
R / Rfree (%) 20.3 / 23.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Prl-1 in Complex with the Bateman Domain of CNNM2 (pdb code 5lxq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Prl-1 in Complex with the Bateman Domain of CNNM2, PDB code: 5lxq:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 5lxq

Go back to Zinc Binding Sites List in 5lxq
Zinc binding site 1 out of 2 in the Structure of Prl-1 in Complex with the Bateman Domain of CNNM2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Prl-1 in Complex with the Bateman Domain of CNNM2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn602

b:79.1
occ:0.83
O2G A:ATP601 2.0 95.8 0.9
O1A A:ATP601 2.6 31.0 0.9
PG A:ATP601 3.0 96.8 0.9
O1B A:ATP601 3.0 55.3 0.9
O3G A:ATP601 3.1 67.4 0.9
O3G H:ATP601 3.1 0.9 0.9
O3B A:ATP601 3.6 89.5 0.9
PB A:ATP601 3.7 72.5 0.9
PA A:ATP601 3.8 29.2 0.9
O3A A:ATP601 3.9 45.7 0.9
PG H:ATP601 4.2 0.5 0.9
O2G H:ATP601 4.3 67.4 0.9
O1G A:ATP601 4.4 94.6 0.9
O2A A:ATP601 4.6 29.1 0.9
O1G H:ATP601 4.7 57.0 0.9
CG A:GLU570 4.8 76.2 1.0
NH2 H:ARG480 4.8 92.0 1.0

Zinc binding site 2 out of 2 in 5lxq

Go back to Zinc Binding Sites List in 5lxq
Zinc binding site 2 out of 2 in the Structure of Prl-1 in Complex with the Bateman Domain of CNNM2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Prl-1 in Complex with the Bateman Domain of CNNM2 within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Zn602

b:84.4
occ:0.83
O2G H:ATP601 2.0 67.4 0.9
O2A H:ATP601 2.6 39.6 0.9
O1G H:ATP601 2.7 57.0 0.9
PG H:ATP601 2.8 0.5 0.9
O2B H:ATP601 3.1 53.2 0.9
O1G A:ATP601 3.3 94.6 0.9
O3B H:ATP601 3.6 74.8 0.9
PB H:ATP601 3.8 68.5 0.9
PA H:ATP601 3.8 29.1 0.9
O3A H:ATP601 4.0 53.6 0.9
O3G H:ATP601 4.1 0.9 0.9
PG A:ATP601 4.3 96.8 0.9
O2G A:ATP601 4.3 95.8 0.9
O1A H:ATP601 4.5 29.0 0.9
O3G A:ATP601 4.6 67.4 0.9
CG H:GLU570 4.6 0.4 1.0
NH2 A:ARG480 4.9 92.2 1.0
CB H:GLU570 5.0 44.9 1.0

Reference:

P.Gimenez-Mascarell, I.Oyenarte, S.Hardy, T.Breiderhoff, M.Stuiver, E.Kostantin, T.Diercks, A.L.Pey, J.Ereno-Orbea, M.L.Martinez-Chantar, R.Khalaf-Nazzal, F.Claverie-Martin, D.Muller, M.L.Tremblay, L.A.Martinez-Cruz. Structural Basis of the Oncogenic Interaction of Phosphatase Prl-1 with the Magnesium Transporter CNNM2. J. Biol. Chem. V. 292 786 2017.
ISSN: ESSN 1083-351X
PubMed: 27899452
DOI: 10.1074/JBC.M116.759944
Page generated: Wed Dec 16 06:31:04 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy