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Zinc in PDB 5lpp: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-4-(2-((3AR,4R,6R,6AR)-6-Methoxy-2,2- Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Ethyl)-2-(Methylamino)- 1H-Imidazo[4,5-G]Quinazolin-8(7H)-One
Enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-4-(2-((3AR,4R,6R,6AR)-6-Methoxy-2,2- Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Ethyl)-2-(Methylamino)- 1H-Imidazo[4,5-G]Quinazolin-8(7H)-One
All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-4-(2-((3AR,4R,6R,6AR)-6-Methoxy-2,2- Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Ethyl)-2-(Methylamino)- 1H-Imidazo[4,5-G]Quinazolin-8(7H)-One:
2.4.2.29;
2.4.2.29;
Protein crystallography data
The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-4-(2-((3AR,4R,6R,6AR)-6-Methoxy-2,2- Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Ethyl)-2-(Methylamino)- 1H-Imidazo[4,5-G]Quinazolin-8(7H)-One, PDB code: 5lpp
was solved by
F.R.Ehrmann,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 42.61 / 1.99 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 85.423, 64.443, 71.223, 90.00, 93.88, 90.00 |
| R / Rfree (%) | 18.1 / 21.6 |
Zinc Binding Sites:
The binding sites of Zinc atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-4-(2-((3AR,4R,6R,6AR)-6-Methoxy-2,2- Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Ethyl)-2-(Methylamino)- 1H-Imidazo[4,5-G]Quinazolin-8(7H)-One
(pdb code 5lpp). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-4-(2-((3AR,4R,6R,6AR)-6-Methoxy-2,2- Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Ethyl)-2-(Methylamino)- 1H-Imidazo[4,5-G]Quinazolin-8(7H)-One, PDB code: 5lpp:
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-4-(2-((3AR,4R,6R,6AR)-6-Methoxy-2,2- Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Ethyl)-2-(Methylamino)- 1H-Imidazo[4,5-G]Quinazolin-8(7H)-One, PDB code: 5lpp:
Zinc binding site 1 out of 1 in 5lpp
Go back to
Zinc Binding Sites List in 5lpp
Zinc binding site 1 out
of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-4-(2-((3AR,4R,6R,6AR)-6-Methoxy-2,2- Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Ethyl)-2-(Methylamino)- 1H-Imidazo[4,5-G]Quinazolin-8(7H)-One
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex (Space Group C2) with 6-Amino-4-(2-((3AR,4R,6R,6AR)-6-Methoxy-2,2- Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)Ethyl)-2-(Methylamino)- 1H-Imidazo[4,5-G]Quinazolin-8(7H)-One within 5.0Å range:
|
Reference:
F.R.Ehrmann,
T.Botzanowski,
T.Pfaffender,
A.Heine,
F.Diederich,
S.Sanglier-Cianferani,
G.Klebe.
Carbohydrate-Based Inhibitors Targeting the Ribose-34 Pocket of Z.Mobilis Tgt and Changing the Oligomeric State of the Homodimer To Be Published.
Page generated: Sun Oct 27 21:14:31 2024
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