Zinc in PDB 5l8w: Structure of USP12-Ub-Prg/UAF1

All present enzymatic activity of Structure of USP12-Ub-Prg/UAF1:
3.4.19.12;

The structure of Structure of USP12-Ub-Prg/UAF1, PDB code: 5l8w was solved by S.Dharadhar, T.Sixma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.40 / 2.79
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	103.679, 152.820, 182.932, 90.00, 90.00, 90.00
R / Rfree (%)	20.8 / 25.9

The binding sites of Zinc atom in the Structure of USP12-Ub-Prg/UAF1 (pdb code 5l8w). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of USP12-Ub-Prg/UAF1, PDB code: 5l8w:

Zinc binding site 1 out of 1 in the Structure of USP12-Ub-Prg/UAF1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of USP12-Ub-Prg/UAF1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:51.0 occ:1.00 SG A:CYS236 2.3 55.3 1.0 SG A:CYS233 2.4 52.4 1.0 SG A:CYS186 2.4 57.3 1.0 SG A:CYS189 2.4 54.3 1.0 CB A:CYS186 3.0 53.0 1.0 CB A:CYS233 3.1 52.5 1.0 CB A:CYS189 3.2 56.0 1.0 CB A:CYS236 3.5 54.3 1.0 N A:CYS189 3.7 54.4 1.0 N A:CYS236 3.9 54.9 1.0 CA A:CYS189 4.0 55.5 1.0 CB A:GLU235 4.4 65.9 1.0 CA A:CYS236 4.4 54.0 1.0 OG1 A:THR188 4.4 59.2 1.0 CA A:CYS186 4.5 52.4 1.0 CA A:CYS233 4.6 53.3 1.0 CG A:GLN240 4.7 49.1 1.0 C A:CYS189 4.9 55.3 1.0 C A:GLU235 4.9 59.5 1.0 C A:CYS186 4.9 51.8 1.0 C A:THR188 4.9 56.6 1.0 CG A:GLU235 4.9 75.0 1.0

S.Dharadhar, M.Clerici, W.J.Van Dijk, A.Fish, T.K.Sixma. A Conserved Two-Step Binding For the UAF1 Regulator to the USP12 Deubiquitinating Enzyme. J.Struct.Biol. V. 196 437 2016.
ISSN: ESSN 1095-8657
PubMed: 27650958
DOI: 10.1016/J.JSB.2016.09.011