Zinc in PDB 5k95: Crystal Structure of Gtp Cyclohydrolase-Ib with 8-Oxo-Gtp

All present enzymatic activity of Crystal Structure of Gtp Cyclohydrolase-Ib with 8-Oxo-Gtp:
3.5.4.16;

The structure of Crystal Structure of Gtp Cyclohydrolase-Ib with 8-Oxo-Gtp, PDB code: 5k95 was solved by J.Alvarez, B.Stec, M.A.Swairjo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.07 / 2.77
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	91.876, 100.557, 115.041, 90.00, 90.00, 90.00
R / Rfree (%)	17.5 / 27.7

The binding sites of Zinc atom in the Crystal Structure of Gtp Cyclohydrolase-Ib with 8-Oxo-Gtp (pdb code 5k95). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Gtp Cyclohydrolase-Ib with 8-Oxo-Gtp, PDB code: 5k95:

Zinc binding site 1 out of 1 in the Crystal Structure of Gtp Cyclohydrolase-Ib with 8-Oxo-Gtp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Gtp Cyclohydrolase-Ib with 8-Oxo-Gtp within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn302 b:55.0 occ:1.00 O8 B:8GT301 1.9 57.0 1.0 NE2 B:HIS159 2.2 50.3 1.0 SG B:CYS147 2.5 59.0 1.0 C8 B:8GT301 2.9 67.2 1.0 CD2 B:HIS159 2.9 50.5 1.0 CB B:CYS147 3.0 59.2 1.0 CE1 B:HIS159 3.3 50.4 1.0 N7 B:8GT301 3.5 69.3 1.0 N9 B:8GT301 3.8 73.5 1.0 CB B:SER150 4.1 67.7 1.0 CD1 B:ILE245 4.1 57.9 1.0 CG B:HIS159 4.1 50.2 1.0 C1' B:8GT301 4.2 80.0 1.0 ND1 B:HIS159 4.3 50.8 1.0 O2' B:8GT301 4.3 72.5 1.0 N B:SER150 4.4 63.8 1.0 C2' B:8GT301 4.4 78.7 1.0 O B:HOH428 4.5 61.4 1.0 CA B:CYS147 4.5 58.7 1.0 C5 B:8GT301 4.7 68.8 1.0 CB B:SNC149 4.7 74.5 1.0 OE2 B:GLU243 4.8 58.5 1.0 CA B:SER150 4.8 66.0 1.0 C4 B:8GT301 4.8 71.1 1.0

N.Paranagama, S.A.Bonnett, J.Alvarez, A.Luthra, B.Stec, A.Gustafson, D.Iwata-Reuyl, M.A.Swairjo. Mechanism and Catalytic Strategy of the Prokaryotic-Specific Gtp Cyclohydrolase-Ib. Biochem.J. V. 474 1017 2017.
ISSN: ESSN 1470-8728
PubMed: 28126741
DOI: 10.1042/BCJ20161025