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Zinc in PDB 5ih5: Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A

Enzymatic activity of Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A

All present enzymatic activity of Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A:
2.7.11.1; 2.7.11.26;

Protein crystallography data

The structure of Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A, PDB code: 5ih5 was solved by A.Ursu, D.J.Illich, Y.Takemoto, A.T.Porfetye, M.Zhang, A.Brockmeyer, P.Janning, N.Watanabe, H.Osada, I.R.Vetter, S.Ziegler, H.R.Schoeler, H.Waldmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.21 / 2.25
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 65.070, 65.070, 151.480, 90.00, 90.00, 120.00
R / Rfree (%) 24 / 26

Other elements in 5ih5:

The structure of Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A (pdb code 5ih5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A, PDB code: 5ih5:

Zinc binding site 1 out of 1 in 5ih5

Go back to Zinc Binding Sites List in 5ih5
Zinc binding site 1 out of 1 in the Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:62.1
occ:1.00
 ND1 A:HIS50 2.1 65.0 1.0
O11 A:SRT303 2.1 76.3 1.0
SG A:CYS71 2.2 64.4 1.0
O1 A:SRT303 2.8 79.2 1.0
C1 A:SRT303 2.8 77.0 1.0
CE1 A:HIS50 2.9 65.1 1.0
CG A:HIS50 3.1 64.9 1.0
CB A:CYS71 3.3 64.9 1.0
CB A:HIS50 3.6 66.2 1.0
O A:CYS71 3.7 73.1 1.0
C A:CYS71 3.7 68.7 1.0
CA A:HIS50 4.0 65.3 1.0
NE2 A:HIS50 4.1 65.7 1.0
N A:GLY72 4.1 69.0 1.0
CA A:CYS71 4.1 66.2 1.0
CD2 A:HIS50 4.2 64.9 1.0
C2 A:SRT303 4.2 79.8 1.0
CA A:GLY72 4.4 70.0 1.0
O3 A:SRT303 4.5 85.8 1.0
C3 A:SRT303 4.7 83.7 1.0
O A:HIS50 4.7 64.4 1.0
C A:HIS50 4.9 63.9 1.0

Reference:

A.Ursu, D.J.Illich, Y.Takemoto, A.T.Porfetye, M.Zhang, A.Brockmeyer, P.Janning, N.Watanabe, H.Osada, I.R.Vetter, S.Ziegler, H.R.Scholer, H.Waldmann. Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells By Inhibition of Casein Kinase 1. Cell Chem Biol V. 23 494 2016.
ISSN: ESSN 2451-9456
PubMed: 27049670
DOI: 10.1016/J.CHEMBIOL.2016.02.015
Page generated: Sun Oct 27 18:03:42 2024

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