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Zinc in PDB 5i43: Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32).
Enzymatic activity of Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32).
All present enzymatic activity of Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32).:
3.4.24.65;
3.4.24.65;
Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32)., PDB code: 5i43
was solved by
E.A.Stura,
L.Rosalia,
D.Cuffaro,
L.Tepshi,
L.Ciccone,
A.Rossello,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 44.56 / 1.95 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 64.030, 63.660, 79.030, 90.00, 103.03, 90.00 |
| R / Rfree (%) | 20 / 23.3 |
Other elements in 5i43:
The structure of Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32). also contains other interesting chemical elements:
| Calcium | (Ca) | 12 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32).
(pdb code 5i43). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32)., PDB code: 5i43:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Zinc where determined in the Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32)., PDB code: 5i43:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Zinc binding site 1 out of 8 in 5i43
Go back to
Zinc Binding Sites List in 5i43
Zinc binding site 1 out
of 8 in the Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32).
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32). within 5.0Å range:
|
Zinc binding site 2 out of 8 in 5i43
Go back to
Zinc Binding Sites List in 5i43
Zinc binding site 2 out
of 8 in the Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32).
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32). within 5.0Å range:
|
Zinc binding site 3 out of 8 in 5i43
Go back to
Zinc Binding Sites List in 5i43
Zinc binding site 3 out
of 8 in the Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32).
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32). within 5.0Å range:
|
Zinc binding site 4 out of 8 in 5i43
Go back to
Zinc Binding Sites List in 5i43
Zinc binding site 4 out
of 8 in the Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32).
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32). within 5.0Å range:
|
Zinc binding site 5 out of 8 in 5i43
Go back to
Zinc Binding Sites List in 5i43
Zinc binding site 5 out
of 8 in the Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32).
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32). within 5.0Å range:
|
Zinc binding site 6 out of 8 in 5i43
Go back to
Zinc Binding Sites List in 5i43
Zinc binding site 6 out
of 8 in the Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32).
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32). within 5.0Å range:
|
Zinc binding site 7 out of 8 in 5i43
Go back to
Zinc Binding Sites List in 5i43
Zinc binding site 7 out
of 8 in the Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32).
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 7 of Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32). within 5.0Å range:
|
Zinc binding site 8 out of 8 in 5i43
Go back to
Zinc Binding Sites List in 5i43
Zinc binding site 8 out
of 8 in the Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32).
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 8 of Crystal Structure of the Catalytic Domain of Mmp-12 in Complex with A Selective Sugar-Conjugated Triazole-Linked Carboxylate Chelator Water-Soluble Inhibitor (DC32). within 5.0Å range:
|
Reference:
E.Nuti,
D.Cuffaro,
F.D'andrea,
L.Rosalia,
L.Tepshi,
M.Fabbi,
G.Carbotti,
S.Ferrini,
S.Santamaria,
C.Camodeca,
L.Ciccone,
E.Orlandini,
S.Nencetti,
E.A.Stura,
V.Dive,
A.Rossello.
Sugar-Based Arylsulfonamide Carboxylates As Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors. Chemmedchem V. 11 1626 2016.
ISSN: ESSN 1860-7187
PubMed: 27356908
DOI: 10.1002/CMDC.201600235
Page generated: Sun Oct 27 17:54:06 2024
ISSN: ESSN 1860-7187
PubMed: 27356908
DOI: 10.1002/CMDC.201600235
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