Atomistry » Zinc » PDB 5hp3-5i3m » 5i07
Atomistry »
  Zinc »
    PDB 5hp3-5i3m »
      5i07 »

Zinc in PDB 5i07: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-(2-Phenylethyl)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One

Enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-(2-Phenylethyl)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One

All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-(2-Phenylethyl)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One:
2.4.2.29;

Protein crystallography data

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-(2-Phenylethyl)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 5i07 was solved by F.R.Ehrmann, D.Nguyen, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.87 / 1.89
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 69.133, 78.854, 85.171, 90.00, 108.99, 90.00
R / Rfree (%) 19.1 / 22

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-(2-Phenylethyl)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One (pdb code 5i07). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-(2-Phenylethyl)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One, PDB code: 5i07:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 5i07

Go back to Zinc Binding Sites List in 5i07
Zinc binding site 1 out of 2 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-(2-Phenylethyl)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-(2-Phenylethyl)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn404

b:19.6
occ:1.00
 ND1 A:HIS349 2.1 20.2 1.0
SG A:CYS323 2.3 21.9 1.0
SG A:CYS320 2.3 23.0 1.0
SG A:CYS318 2.3 21.5 1.0
CE1 A:HIS349 2.9 19.8 1.0
CG A:HIS349 3.3 19.7 1.0
CB A:CYS318 3.3 22.6 1.0
CB A:CYS323 3.3 25.4 1.0
CB A:CYS320 3.4 22.9 1.0
CB A:HIS349 3.7 19.2 1.0
N A:CYS323 3.9 21.4 1.0
NE2 A:HIS349 4.1 20.6 1.0
N A:CYS320 4.2 25.6 1.0
CA A:HIS349 4.2 21.4 1.0
CA A:CYS323 4.2 23.1 1.0
CA A:CYS320 4.2 24.1 1.0
CD2 A:HIS349 4.3 19.8 1.0
O A:HIS349 4.5 18.5 1.0
CA A:CYS318 4.6 24.0 1.0
C A:CYS320 4.7 27.4 1.0
O A:CYS320 4.7 27.2 1.0
C A:CYS318 4.7 25.5 1.0
CB A:VAL322 4.8 22.2 1.0
C A:HIS349 4.8 20.8 1.0
O A:CYS318 4.9 27.7 1.0
C A:VAL322 5.0 25.6 1.0

Zinc binding site 2 out of 2 in 5i07

Go back to Zinc Binding Sites List in 5i07
Zinc binding site 2 out of 2 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-(2-Phenylethyl)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-(2-Phenylethyl)-1,7-Dihydro-8H-Imidazo[4,5-G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn402

b:19.7
occ:1.00
 ND1 B:HIS349 2.1 21.3 1.0
SG B:CYS323 2.2 23.2 1.0
SG B:CYS318 2.2 22.3 1.0
SG B:CYS320 2.4 22.7 1.0
CE1 B:HIS349 2.9 21.0 1.0
CB B:CYS318 3.2 22.4 1.0
CG B:HIS349 3.3 18.4 1.0
CB B:CYS323 3.3 24.1 1.0
CB B:CYS320 3.4 22.2 1.0
CB B:HIS349 3.7 19.1 1.0
N B:CYS323 3.9 22.3 1.0
NE2 B:HIS349 4.1 20.6 1.0
N B:CYS320 4.2 26.9 1.0
CA B:HIS349 4.2 20.4 1.0
CA B:CYS323 4.2 22.6 1.0
CA B:CYS320 4.3 22.2 1.0
CD2 B:HIS349 4.3 17.4 1.0
O B:HIS349 4.5 19.0 1.0
CA B:CYS318 4.5 24.4 1.0
C B:CYS318 4.7 24.5 1.0
C B:CYS320 4.8 26.8 1.0
O B:CYS320 4.8 26.4 1.0
CB B:VAL322 4.8 20.8 1.0
C B:HIS349 4.8 19.0 1.0
O B:CYS318 4.8 25.7 1.0
C B:VAL322 5.0 22.4 1.0

Reference:

F.R.Ehrmann, J.Stojko, A.Heine, F.Diederich, K.Reiter, S.Sanglier-Cianferani, G.Klebe. Co-Crystallization, Isothermal Titration Calorimetry and Nanoesi-Ms Reveal Dimer Disturbing Inhibitors To Be Published.
Page generated: Thu Aug 21 03:14:20 2025

Last articles

Zn in 5RLO
Zn in 5RLP
Zn in 5RLN
Zn in 5RLM
Zn in 5RLJ
Zn in 5RLL
Zn in 5RLK
Zn in 5RLI
Zn in 5RLH
Zn in 5RLG
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy