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Zinc in PDB 5i06: Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methoxyphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One

Enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methoxyphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One

All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methoxyphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methoxyphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One, PDB code: 5i06 was solved by F.R.Ehrmann, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.33 / 1.36
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 84.852, 64.915, 71.174, 90.00, 93.85, 90.00
R / Rfree (%) 14.3 / 17.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methoxyphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One (pdb code 5i06). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methoxyphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One, PDB code: 5i06:

Zinc binding site 1 out of 1 in 5i06

Go back to Zinc Binding Sites List in 5i06
Zinc binding site 1 out of 1 in the Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methoxyphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methoxyphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:18.6
occ:1.00
 ND1 A:HIS349 2.1 16.9 1.0
SG A:CYS323 2.3 18.8 1.0
SG A:CYS318 2.3 19.7 1.0
SG A:CYS320 2.3 19.7 1.0
CE1 A:HIS349 2.9 17.9 1.0
CG A:HIS349 3.3 15.7 1.0
CB A:CYS323 3.3 19.7 1.0
CB A:CYS318 3.3 20.0 1.0
CB A:CYS320 3.3 21.1 1.0
CB A:HIS349 3.8 16.6 1.0
N A:CYS323 3.9 19.8 1.0
NE2 A:HIS349 4.1 16.9 1.0
N A:CYS320 4.1 23.4 1.0
CA A:HIS349 4.2 16.7 1.0
CA A:CYS320 4.2 22.5 1.0
CA A:CYS323 4.2 19.9 1.0
CD2 A:HIS349 4.3 16.4 1.0
O A:HIS349 4.5 16.9 1.0
CA A:CYS318 4.6 21.9 1.0
C A:CYS320 4.7 23.5 1.0
O A:CYS320 4.7 24.1 1.0
C A:CYS318 4.7 23.3 1.0
C A:HIS349 4.8 16.7 1.0
CB A:VAL322 4.8 20.6 1.0
O A:CYS318 4.8 24.2 1.0
C A:VAL322 5.0 20.8 1.0

Reference:

F.R.Ehrmann, J.Stojko, A.Heine, F.Diederich, K.Reuter, S.Sanglier-Cianferani, G.Klebe. Co-Crystallization, Isothermal Titration Calorimetry and Nanoesi-Ms Reveal Dimer Disturbing Inhibitors To Be Published.
Page generated: Sun Oct 27 17:44:01 2024

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