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Zinc in PDB 5i03: Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One

Enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One

All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One, PDB code: 5i03 was solved by F.R.Ehrmann, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.49 / 1.73
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 85.140, 64.641, 71.017, 90.00, 93.60, 90.00
R / Rfree (%) 18.1 / 20.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One (pdb code 5i03). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One, PDB code: 5i03:

Zinc binding site 1 out of 1 in 5i03

Go back to Zinc Binding Sites List in 5i03
Zinc binding site 1 out of 1 in the Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna-Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-4-[2-(4-Methylphenyl)Ethyl]-1,7-Dihydro-8H-Imidazo[4,5- G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn403

b:21.8
occ:1.00
 ND1 A:HIS349 2.2 17.2 1.0
SG A:CYS320 2.3 24.5 1.0
SG A:CYS323 2.3 24.6 1.0
SG A:CYS318 2.3 27.3 1.0
CE1 A:HIS349 3.0 16.6 1.0
CB A:CYS318 3.3 26.4 1.0
CG A:HIS349 3.3 18.2 1.0
CB A:CYS323 3.3 24.8 1.0
CB A:CYS320 3.3 24.2 1.0
CB A:HIS349 3.8 20.1 1.0
N A:CYS323 3.9 26.2 1.0
N A:CYS320 4.1 23.4 1.0
NE2 A:HIS349 4.2 15.2 1.0
CA A:HIS349 4.2 20.8 1.0
CA A:CYS320 4.2 24.4 1.0
CA A:CYS323 4.3 25.2 1.0
CD2 A:HIS349 4.4 16.3 1.0
O A:HIS349 4.5 20.6 1.0
CA A:CYS318 4.6 26.3 1.0
C A:CYS318 4.7 27.1 1.0
O A:CYS320 4.7 23.2 1.0
C A:CYS320 4.7 24.3 1.0
C A:HIS349 4.8 20.0 1.0
CB A:VAL322 4.8 26.1 1.0
O A:CYS318 4.8 27.1 1.0
CB A:LEU314 5.0 19.8 1.0
C A:VAL322 5.0 25.7 1.0

Reference:

F.R.Ehrmann, J.Stojko, A.Heine, F.Diederich, K.Reuter, S.Sanglier-Cianferani, G.Klebe. Co-Crystallization, Isothermal Titration Calorimetry and Nanoesi-Ms Reveal Dimer Disturbing Inhibitors To Be Published.
Page generated: Sun Oct 27 17:44:01 2024

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