Atomistry » Zinc » PDB 5hmy-5i1r » 5hrq
Atomistry »
  Zinc »
    PDB 5hmy-5i1r »
      5hrq »

Zinc in PDB 5hrq: Insulin with Proline Analog Hzp at Position B28 in the R6 State

Protein crystallography data

The structure of Insulin with Proline Analog Hzp at Position B28 in the R6 State, PDB code: 5hrq was solved by S.A.Lieblich, K.Y.Fang, J.K.B.Cahn, D.A.Tirrell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 56.70 / 1.28
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 47.156, 60.680, 60.665, 90.00, 110.82, 90.00
R / Rfree (%) 13.5 / 16.8

Other elements in 5hrq:

The structure of Insulin with Proline Analog Hzp at Position B28 in the R6 State also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Insulin with Proline Analog Hzp at Position B28 in the R6 State (pdb code 5hrq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Insulin with Proline Analog Hzp at Position B28 in the R6 State, PDB code: 5hrq:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 5hrq

Go back to Zinc Binding Sites List in 5hrq
Zinc binding site 1 out of 2 in the Insulin with Proline Analog Hzp at Position B28 in the R6 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Insulin with Proline Analog Hzp at Position B28 in the R6 State within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn301

b:12.7
occ:1.00
NE2 B:HIS10 2.0 14.2 1.0
NE2 J:HIS10 2.0 12.7 1.0
NE2 F:HIS10 2.1 12.9 1.0
CL F:CL101 2.2 14.5 1.0
CE1 B:HIS10 3.0 20.2 1.0
CE1 J:HIS10 3.0 16.2 1.0
CE1 F:HIS10 3.0 16.1 1.0
CD2 B:HIS10 3.0 12.4 1.0
CD2 J:HIS10 3.0 12.0 1.0
CD2 F:HIS10 3.1 12.6 1.0
ND1 B:HIS10 4.1 19.9 1.0
ND1 J:HIS10 4.1 15.6 1.0
ND1 F:HIS10 4.1 14.8 1.0
CG B:HIS10 4.2 13.3 1.0
CG J:HIS10 4.2 11.7 1.0
CG F:HIS10 4.2 12.6 1.0
O B:LEU6 4.7 14.1 1.0
CB B:LEU6 4.8 13.4 1.0
O F:LEU6 4.8 16.2 1.0
O J:LEU6 4.8 13.5 1.0
O B:HOH403 4.8 39.0 1.0
CB J:LEU6 4.9 14.8 1.0
CB F:LEU6 4.9 17.2 1.0
O J:HOH103 4.9 25.9 1.0
O F:HOH207 4.9 32.1 1.0

Zinc binding site 2 out of 2 in 5hrq

Go back to Zinc Binding Sites List in 5hrq
Zinc binding site 2 out of 2 in the Insulin with Proline Analog Hzp at Position B28 in the R6 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Insulin with Proline Analog Hzp at Position B28 in the R6 State within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn101

b:12.3
occ:1.00
NE2 H:HIS10 2.0 12.9 1.0
NE2 D:HIS10 2.1 12.3 1.0
NE2 L:HIS10 2.1 11.8 1.0
CL H:CL101 2.2 14.5 1.0
CE1 H:HIS10 3.0 17.7 1.0
CD2 H:HIS10 3.0 11.4 1.0
CE1 D:HIS10 3.0 15.7 1.0
CE1 L:HIS10 3.0 15.9 1.0
CD2 L:HIS10 3.1 11.2 1.0
CD2 D:HIS10 3.1 12.4 1.0
ND1 H:HIS10 4.1 18.3 1.0
ND1 D:HIS10 4.1 16.4 1.0
CG H:HIS10 4.2 13.3 1.0
ND1 L:HIS10 4.2 16.5 1.0
CG D:HIS10 4.2 12.2 1.0
CG L:HIS10 4.2 11.5 1.0
O D:LEU6 4.8 15.7 1.0
O H:LEU6 4.8 14.2 1.0
CB L:LEU6 4.8 14.1 1.0
O D:HOH208 4.8 29.0 1.0
CB H:LEU6 4.9 14.5 1.0
O L:LEU6 4.9 13.1 1.0
CB D:LEU6 4.9 14.6 1.0

Reference:

S.A.Lieblich, K.Y.Fang, J.K.B.Cahn, J.Rawson, J.Lebon, H.T.Ku, D.A.Tirrell. 4S-Hydroxylation of Insulin at PROB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc. V. 139 8384 2017.
ISSN: ESSN 1520-5126
PubMed: 28598606
DOI: 10.1021/JACS.7B00794
Page generated: Wed Dec 16 06:20:50 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy