Atomistry » Zinc » PDB 5gm3-5h7r » 5gut
Atomistry »
  Zinc »
    PDB 5gm3-5h7r »
      5gut »

Zinc in PDB 5gut: The Crystal Structure of Mouse DNMT1 (731-1602) Mutant - N1248A

Enzymatic activity of The Crystal Structure of Mouse DNMT1 (731-1602) Mutant - N1248A

All present enzymatic activity of The Crystal Structure of Mouse DNMT1 (731-1602) Mutant - N1248A:
2.1.1.37;

Protein crystallography data

The structure of The Crystal Structure of Mouse DNMT1 (731-1602) Mutant - N1248A, PDB code: 5gut was solved by S.J.Chen, F.Ye, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.36 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 75.424, 78.554, 164.544, 90.00, 90.00, 90.00
R / Rfree (%) 20 / 23.1

Zinc Binding Sites:

The binding sites of Zinc atom in the The Crystal Structure of Mouse DNMT1 (731-1602) Mutant - N1248A (pdb code 5gut). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the The Crystal Structure of Mouse DNMT1 (731-1602) Mutant - N1248A, PDB code: 5gut:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 5gut

Go back to Zinc Binding Sites List in 5gut
Zinc binding site 1 out of 2 in the The Crystal Structure of Mouse DNMT1 (731-1602) Mutant - N1248A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Crystal Structure of Mouse DNMT1 (731-1602) Mutant - N1248A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1702

b:50.4
occ:1.00
NE2 A:HIS796 2.2 58.9 1.0
SG A:CYS900 2.2 49.0 1.0
SG A:CYS823 2.3 44.2 1.0
SG A:CYS897 2.3 51.6 1.0
CB A:CYS823 2.9 43.5 1.0
CD2 A:HIS796 3.1 52.6 1.0
CE1 A:HIS796 3.2 57.1 1.0
CB A:CYS897 3.3 63.1 1.0
CB A:CYS900 3.4 41.5 1.0
N A:CYS900 3.4 53.4 1.0
CA A:CYS900 3.8 55.5 1.0
CB A:SER899 4.1 51.4 1.0
CG A:HIS796 4.3 62.2 1.0
ND1 A:HIS796 4.3 57.1 1.0
C A:SER899 4.4 47.0 1.0
CA A:CYS823 4.4 51.3 1.0
OG A:SER899 4.5 45.9 1.0
O A:CYS897 4.6 44.1 1.0
CA A:CYS897 4.6 58.9 1.0
CA A:SER899 4.7 46.1 1.0
C A:CYS823 4.8 59.6 1.0
C A:CYS897 4.8 57.1 1.0
N A:SER899 4.9 43.4 1.0
N A:GLU824 5.0 52.5 1.0

Zinc binding site 2 out of 2 in 5gut

Go back to Zinc Binding Sites List in 5gut
Zinc binding site 2 out of 2 in the The Crystal Structure of Mouse DNMT1 (731-1602) Mutant - N1248A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Crystal Structure of Mouse DNMT1 (731-1602) Mutant - N1248A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1703

b:25.2
occ:1.00
NE2 A:HIS1504 2.1 22.2 1.0
SG A:CYS1481 2.3 27.9 1.0
SG A:CYS1487 2.4 28.8 1.0
SG A:CYS1479 2.4 26.3 1.0
CD2 A:HIS1504 3.0 16.8 1.0
CB A:CYS1479 3.2 25.0 1.0
CE1 A:HIS1504 3.2 28.7 1.0
CB A:CYS1481 3.2 31.5 1.0
CB A:CYS1487 3.3 26.0 1.0
CA A:CYS1487 3.9 30.7 1.0
N A:CYS1481 4.0 25.5 1.0
CG A:HIS1504 4.2 29.5 1.0
ND1 A:HIS1504 4.2 26.5 1.0
CA A:CYS1481 4.3 28.5 1.0
O A:HOH2253 4.3 44.5 1.0
CA A:CYS1479 4.6 24.8 1.0
OG A:SER1491 4.7 30.6 1.0
N A:CYS1487 4.8 33.5 1.0
C A:CYS1479 4.8 29.2 1.0
O A:HOH2110 4.9 34.7 1.0
N A:SER1480 4.9 28.4 1.0
C A:CYS1487 5.0 35.0 1.0
O A:HOH1934 5.0 24.9 1.0

Reference:

F.Ye, X.Kong, H.Zhang, Y.Liu, Z.Shao, J.Jin, Y.Cai, R.Zhang, L.Li, Y.W.Zhang, Y.C.Liu, C.Zhang, W.Xie, K.Yu, H.Ding, K.Zhao, S.Chen, H.Jiang, S.B.Baylin, C.Luo. Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in Dna Methyltransferase-1. Acs Chem. Biol. V. 13 772 2018.
ISSN: ESSN 1554-8937
PubMed: 29381856
DOI: 10.1021/ACSCHEMBIO.7B00890
Page generated: Sun Oct 27 17:12:00 2024

Last articles

Al in 3N5K
Al in 3PUW
Al in 3QPW
Al in 3LVR
Al in 3HB1
Al in 3KQL
Al in 3CMX
Al in 3LVQ
Al in 3I62
Al in 3EX7
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy