Zinc in PDB 5gpo: The Sensor Domain Structure of the Zinc-Responsive Histidine Kinase Czcs From Pseudomonas Aeruginosa

All present enzymatic activity of The Sensor Domain Structure of the Zinc-Responsive Histidine Kinase Czcs From Pseudomonas Aeruginosa:
2.7.13.3;

The structure of The Sensor Domain Structure of the Zinc-Responsive Histidine Kinase Czcs From Pseudomonas Aeruginosa, PDB code: 5gpo was solved by D.Wang, W.Z.Chen, S.Q.Huang, X.C.Liu, Q.Y.Hu, T.B.Wei, J.H.Gan, H.Chen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.75 / 1.70
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	93.337, 47.705, 57.528, 90.00, 91.63, 90.00
R / Rfree (%)	21 / 25.3

The binding sites of Zinc atom in the The Sensor Domain Structure of the Zinc-Responsive Histidine Kinase Czcs From Pseudomonas Aeruginosa (pdb code 5gpo). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the The Sensor Domain Structure of the Zinc-Responsive Histidine Kinase Czcs From Pseudomonas Aeruginosa, PDB code: 5gpo:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the The Sensor Domain Structure of the Zinc-Responsive Histidine Kinase Czcs From Pseudomonas Aeruginosa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Sensor Domain Structure of the Zinc-Responsive Histidine Kinase Czcs From Pseudomonas Aeruginosa within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:21.9 occ:0.50 OD2 A:ASP60 2.0 21.9 1.0 NE2 A:HIS55 2.1 25.1 1.0 CG A:ASP60 2.7 28.9 1.0 OD1 A:ASP60 2.7 24.4 1.0 CD2 A:HIS55 2.9 18.7 1.0 CE1 A:HIS55 3.2 22.6 1.0 CG A:HIS55 4.1 20.4 1.0 CB A:ASP60 4.1 25.8 1.0 ND1 A:HIS55 4.2 26.2 1.0 O A:HOH345 4.3 37.4 1.0 O A:HOH400 4.5 37.8 1.0 O A:HOH351 4.5 37.6 1.0

Zinc binding site 2 out of 2 in the The Sensor Domain Structure of the Zinc-Responsive Histidine Kinase Czcs From Pseudomonas Aeruginosa


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Sensor Domain Structure of the Zinc-Responsive Histidine Kinase Czcs From Pseudomonas Aeruginosa within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:27.0 occ:1.00 NE2 B:HIS72 1.9 28.6 1.0 NE2 A:HIS72 2.1 30.6 1.0 OD2 B:ASP76 2.1 34.3 1.0 CE1 B:HIS72 2.7 28.5 1.0 CG B:ASP76 2.9 26.1 1.0 CE1 A:HIS72 2.9 26.1 1.0 CD2 B:HIS72 3.0 32.0 1.0 OD1 B:ASP76 3.0 26.1 1.0 CD2 A:HIS72 3.1 26.5 1.0 ND1 B:HIS72 3.8 37.9 1.0 CG B:HIS72 4.0 27.8 1.0 ND1 A:HIS72 4.1 22.7 1.0 CG A:HIS72 4.2 25.2 1.0 CB B:ASP76 4.3 22.0 1.0 O B:HOH380 4.7 35.0 1.0 NE2 A:GLN75 4.8 28.4 1.0 O B:HIS72 4.9 27.7 1.0

D.Wang, W.Chen, S.Huang, Y.He, X.Liu, Q.Hu, T.Wei, H.Shang, J.Gan, H.Chen. Structural Basis of Zn(II) Induced Metal Detoxification and Antibiotic Resistance By Histidine Kinase Czcs in Pseudomonas Aeruginosa Plos Pathog. V. 13 06533 2017.
ISSN: ESSN 1553-7374
PubMed: 28732057
DOI: 10.1371/JOURNAL.PPAT.1006533