Zinc in PDB 5flx: Mammalian 40S Hcv-Ires Complex

All present enzymatic activity of Mammalian 40S Hcv-Ires Complex:
4.2.99.18;

The structure of Mammalian 40S Hcv-Ires Complex also contains other interesting chemical elements:

Magnesium

(Mg)

74 atoms

The binding sites of Zinc atom in the Mammalian 40S Hcv-Ires Complex (pdb code 5flx). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Mammalian 40S Hcv-Ires Complex, PDB code: 5flx:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Mammalian 40S Hcv-Ires Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Mammalian 40S Hcv-Ires Complex within 5.0Å range: probe atom residue distance (Å) B Occ a:Zn201 b:20.0 occ:1.00 O a:ASN25 2.1 20.0 1.0 O a:THR24 2.2 20.0 1.0 CB a:ALA27 2.5 20.0 1.0 C a:ASN25 2.7 20.0 1.0 C a:THR24 2.9 20.0 1.0 CA a:ASN25 3.1 20.0 1.0 N a:ASN25 3.2 20.0 1.0 CA a:ALA27 3.6 20.0 1.0 N a:ALA27 3.7 20.0 1.0 C a:CYS26 3.8 20.0 1.0 N a:CYS26 3.8 20.0 1.0 CA a:THR24 4.1 20.0 1.0 CA a:CYS26 4.2 20.0 1.0 O a:CYS26 4.2 20.0 1.0 O a:CYS23 4.2 20.0 1.0 CB a:ASN25 4.6 20.0 1.0 N a:THR24 4.7 20.0 1.0 C a:CYS23 4.8 20.0 1.0 C a:ALA27 4.9 20.0 1.0 NH2 O:ARG142 5.0 20.0 1.0

Zinc binding site 2 out of 2 in the Mammalian 40S Hcv-Ires Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Mammalian 40S Hcv-Ires Complex within 5.0Å range: probe atom residue distance (Å) B Occ d:Zn101 b:20.0 occ:1.00 SG d:CYS39 2.5 20.0 1.0 CG1 d:VAL23 2.6 20.0 1.0 CB d:VAL23 2.6 20.0 1.0 N d:CYS24 2.6 20.0 1.0 SG d:CYS24 2.7 20.0 1.0 CB d:CYS24 2.9 20.0 1.0 CA d:CYS24 3.3 20.0 1.0 SG d:CYS42 3.4 20.0 1.0 C d:VAL23 3.4 20.0 1.0 CA d:VAL23 3.5 20.0 1.0 CG2 d:VAL23 3.8 20.0 1.0 SG d:CYS21 4.1 20.0 1.0 CB d:CYS39 4.2 20.0 1.0 N d:VAL23 4.3 20.0 1.0 O d:VAL23 4.4 20.0 1.0 C d:CYS24 4.5 20.0 1.0 N2 1:G1495 4.5 20.0 1.0 N3 1:G1495 4.7 20.0 1.0 CB d:CYS42 4.8 20.0 1.0 N d:SER25 4.9 20.0 1.0 O2' 1:G1495 5.0 20.0 1.0

H.Yamamoto, M.Collier, J.Loerke, J.Ismer, A.Schmidt, T.Hilal, T.Sprink, K.Yamamoto, T.Mielke, J.Burger, T.R.Shaikh, M.Dabrowski, P.W.Hildebrand, P.Scheerer, C.M.Spahn. Molecular Architecture of the Ribosome-Bound Hepatitis C Virus Internal Ribosomal Entry Site Rna. Embo J. V. 34 3042 2015.
ISSN: ISSN 0261-4189
PubMed: 26604301
DOI: 10.15252/EMBJ.201592469