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Atomistry » Zinc » PDB 5evk-5f8g » 5f5i | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 5evk-5f8g » 5f5i » |
Zinc in PDB 5f5i: Crystal Structure of Human JMJD2A Complexed with KDOOA011340Protein crystallography data
The structure of Crystal Structure of Human JMJD2A Complexed with KDOOA011340, PDB code: 5f5i
was solved by
T.Krojer,
M.Vollmar,
L.Crawley,
A.Szykowska,
C.Gileadi,
C.Johansson,
K.England,
H.Yang,
N.Burgess-Brown,
P.Brennan,
C.Bountra,
C.H.Arrowsmith,
A.Edwards,
U.Oppermann,
F.Von Delft,
Structural Genomics Consortium(Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5f5i:
The structure of Crystal Structure of Human JMJD2A Complexed with KDOOA011340 also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human JMJD2A Complexed with KDOOA011340
(pdb code 5f5i). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human JMJD2A Complexed with KDOOA011340, PDB code: 5f5i: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 5f5iGo back to Zinc Binding Sites List in 5f5i
Zinc binding site 1 out
of 2 in the Crystal Structure of Human JMJD2A Complexed with KDOOA011340
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 5f5iGo back to Zinc Binding Sites List in 5f5i
Zinc binding site 2 out
of 2 in the Crystal Structure of Human JMJD2A Complexed with KDOOA011340
Mono view Stereo pair view
Reference:
V.Bavetsias,
R.M.Lanigan,
G.F.Ruda,
B.Atrash,
M.G.Mclaughlin,
A.Tumber,
N.Y.Mok,
Y.V.Le Bihan,
S.Dempster,
K.J.Boxall,
F.Jeganathan,
S.B.Hatch,
P.Savitsky,
S.Velupillai,
T.Krojer,
K.S.England,
J.Sejberg,
C.Thai,
A.Donovan,
A.Pal,
G.Scozzafava,
J.M.Bennett,
A.Kawamura,
C.Johansson,
A.Szykowska,
C.Gileadi,
N.A.Burgess-Brown,
F.Von Delft,
U.Oppermann,
Z.Walters,
J.Shipley,
F.I.Raynaud,
S.M.Westaway,
R.K.Prinjha,
O.Fedorov,
R.Burke,
C.J.Schofield,
I.M.Westwood,
C.Bountra,
S.Muller,
R.L.Van Montfort,
P.E.Brennan,
J.Blagg.
8-Substituted Pyrido[3,4-D]Pyrimidin-4(3H)-One Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem. V. 59 1388 2016.
Page generated: Wed Dec 16 06:13:02 2020
ISSN: ISSN 0022-2623 PubMed: 26741168 DOI: 10.1021/ACS.JMEDCHEM.5B01635 |
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