Zinc in PDB 5exh: Crystal Structure of MTET3-Cxxc Domain in Complex with 5- Carboxylcytosine Dna at 1.3 Angstroms Resolution.

The structure of Crystal Structure of MTET3-Cxxc Domain in Complex with 5- Carboxylcytosine Dna at 1.3 Angstroms Resolution., PDB code: 5exh was solved by J.Song, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	32.63 / 1.30
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	74.959, 27.230, 47.060, 90.00, 104.44, 90.00
R / Rfree (%)	16.8 / 18.7

The binding sites of Zinc atom in the Crystal Structure of MTET3-Cxxc Domain in Complex with 5- Carboxylcytosine Dna at 1.3 Angstroms Resolution. (pdb code 5exh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of MTET3-Cxxc Domain in Complex with 5- Carboxylcytosine Dna at 1.3 Angstroms Resolution., PDB code: 5exh:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of MTET3-Cxxc Domain in Complex with 5- Carboxylcytosine Dna at 1.3 Angstroms Resolution.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of MTET3-Cxxc Domain in Complex with 5- Carboxylcytosine Dna at 1.3 Angstroms Resolution. within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn201 b:12.0 occ:1.00 SG C:CYS57 2.3 13.3 1.0 SG C:CYS89 2.3 10.9 1.0 SG C:CYS60 2.3 11.6 1.0 SG C:CYS63 2.4 11.3 1.0 CB C:CYS89 3.2 9.1 1.0 CB C:CYS63 3.3 12.2 1.0 CB C:CYS57 3.4 14.4 1.0 CB C:CYS60 3.4 13.6 1.0 N C:CYS57 3.6 13.1 1.0 CA C:CYS89 3.6 9.0 1.0 N C:GLY58 3.8 12.9 1.0 N C:CYS60 3.8 14.1 1.0 CA C:CYS57 3.9 13.9 1.0 N C:GLU90 4.0 9.9 1.0 CA C:CYS60 4.2 15.2 1.0 C C:CYS89 4.2 9.1 1.0 C C:CYS57 4.2 12.8 1.0 N C:THR59 4.4 12.6 1.0 N C:CYS63 4.4 11.8 1.0 CA C:CYS63 4.4 11.7 1.0 N C:VAL91 4.7 11.2 1.0 C C:ARG56 4.7 12.2 1.0 CA C:GLY58 4.8 14.2 1.0 CG2 C:VAL91 4.9 14.9 1.0 O C:CYS60 4.9 15.5 1.0 C C:CYS60 4.9 14.7 1.0 N C:CYS89 4.9 9.0 1.0 C C:GLY58 4.9 14.1 1.0 O C:HOH360 4.9 24.5 1.0 CB C:ARG56 4.9 11.8 0.4 C C:THR59 5.0 15.1 1.0 CB C:ARG56 5.0 11.7 0.6

Zinc binding site 2 out of 2 in the Crystal Structure of MTET3-Cxxc Domain in Complex with 5- Carboxylcytosine Dna at 1.3 Angstroms Resolution.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of MTET3-Cxxc Domain in Complex with 5- Carboxylcytosine Dna at 1.3 Angstroms Resolution. within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn202 b:10.3 occ:1.00 SG C:CYS69 2.3 11.0 1.0 SG C:CYS84 2.3 10.1 1.0 SG C:CYS72 2.3 9.6 1.0 SG C:CYS75 2.4 10.2 1.0 CB C:CYS84 3.2 8.4 1.0 CB C:CYS72 3.4 9.7 1.0 CB C:CYS75 3.4 12.6 1.0 CB C:CYS69 3.4 11.5 1.0 N C:CYS69 3.5 12.2 1.0 CA C:CYS84 3.6 9.7 1.0 N C:CYS72 3.8 10.4 1.0 N C:GLY70 3.9 12.3 1.0 CA C:CYS69 3.9 11.5 1.0 N C:LYS85 4.0 8.9 1.0 CA C:CYS72 4.2 10.3 1.0 C C:CYS84 4.2 8.1 1.0 N C:CYS75 4.2 10.0 1.0 C C:CYS69 4.3 12.0 1.0 CA C:CYS75 4.4 11.8 1.0 N C:SER71 4.5 11.2 1.0 C C:ASN68 4.6 13.8 1.0 N C:LEU86 4.6 8.7 1.0 CD2 C:LEU86 4.7 18.9 1.0 C C:CYS72 4.8 9.5 1.0 CA C:GLY70 4.9 12.3 1.0 O C:CYS72 4.9 9.8 1.0 N C:CYS84 4.9 9.2 1.0 CA C:ASN68 5.0 11.2 1.0

S.G.Jin, Z.M.Zhang, T.L.Dunwell, M.R.Harter, X.Wu, J.Johnson, Z.Li, J.Liu, P.E.Szabo, Q.Lu, G.L.Xu, J.Song, G.P.Pfeifer. TET3 Reads 5-Carboxylcytosine Through Its Cxxc Domain and Is A Potential Guardian Against Neurodegeneration. Cell Rep V. 14 493 2016.
ISSN: ESSN 2211-1247
PubMed: 26774490
DOI: 10.1016/J.CELREP.2015.12.044