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Zinc in PDB 5esv: Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256.
Enzymatic activity of Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256.
All present enzymatic activity of Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256.:
4.6.1.12;
4.6.1.12;
Protein crystallography data
The structure of Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256., PDB code: 5esv
was solved by
J.Gorman,
M.Yang,
P.D.Kwong,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 41.99 / 3.11 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 162.693, 98.211, 170.629, 90.00, 112.82, 90.00 |
| R / Rfree (%) | 20.9 / 25.9 |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256.
(pdb code 5esv). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256., PDB code: 5esv:
Jump to Zinc binding site number: 1; 2; 3;
In total 3 binding sites of Zinc where determined in the Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256., PDB code: 5esv:
Jump to Zinc binding site number: 1; 2; 3;
Zinc binding site 1 out of 3 in 5esv
Go back to
Zinc Binding Sites List in 5esv
Zinc binding site 1 out
of 3 in the Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256. within 5.0Å range:
|
Zinc binding site 2 out of 3 in 5esv
Go back to
Zinc Binding Sites List in 5esv
Zinc binding site 2 out
of 3 in the Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256. within 5.0Å range:
|
Zinc binding site 3 out of 3 in 5esv
Go back to
Zinc Binding Sites List in 5esv
Zinc binding site 3 out
of 3 in the Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Crystal Structure of Broadly Neutralizing Antibody CH03, Isolated From Donor CH0219, in Complex with Scaffolded Trimeric Hiv-1 Env V1V2 Domain From the Clade C Superinfecting Strain of Donor CAP256. within 5.0Å range:
|
Reference:
J.Gorman,
C.Soto,
M.M.Yang,
T.M.Davenport,
M.Guttman,
R.T.Bailer,
M.Chambers,
G.Y.Chuang,
B.J.Dekosky,
N.A.Doria-Rose,
A.Druz,
M.J.Ernandes,
I.S.Georgiev,
M.C.Jarosinski,
M.G.Joyce,
T.M.Lemmin,
S.Leung,
M.K.Louder,
J.R.Mcdaniel,
S.Narpala,
M.Pancera,
J.Stuckey,
X.Wu,
Y.Yang,
B.Zhang,
T.Zhou,
N.C.Program,
J.C.Mullikin,
U.Baxa,
G.Georgiou,
A.B.Mcdermott,
M.Bonsignori,
B.F.Haynes,
P.L.Moore,
L.Morris,
K.K.Lee,
L.Shapiro,
J.R.Mascola,
P.D.Kwong.
Structures of Hiv-1 Env V1V2 with Broadly Neutralizing Antibodies Reveal Commonalities That Enable Vaccine Design. Nat.Struct.Mol.Biol. V. 23 81 2016.
ISSN: ESSN 1545-9985
PubMed: 26689967
DOI: 10.1038/NSMB.3144
Page generated: Wed Dec 16 06:10:25 2020
ISSN: ESSN 1545-9985
PubMed: 26689967
DOI: 10.1038/NSMB.3144
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