Atomistry » Zinc » PDB 5bqm-5c2e » 5bqq
Atomistry »
  Zinc »
    PDB 5bqm-5c2e »
      5bqq »

Zinc in PDB 5bqq: Human Insulin with Intra-Chain Chemical Crosslink Between Modified B27 and B30

Protein crystallography data

The structure of Human Insulin with Intra-Chain Chemical Crosslink Between Modified B27 and B30, PDB code: 5bqq was solved by A.M.Brzozowski, J.P.Turkenburg, J.Jiracek, L.Zakova, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 52.82 / 1.54
Space group P 31
Cell size a, b, c (Å), α, β, γ (°) 60.992, 60.992, 81.919, 90.00, 90.00, 120.00
R / Rfree (%) 16.1 / 19.5

Other elements in 5bqq:

The structure of Human Insulin with Intra-Chain Chemical Crosslink Between Modified B27 and B30 also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Insulin with Intra-Chain Chemical Crosslink Between Modified B27 and B30 (pdb code 5bqq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Insulin with Intra-Chain Chemical Crosslink Between Modified B27 and B30, PDB code: 5bqq:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 5bqq

Go back to Zinc Binding Sites List in 5bqq
Zinc binding site 1 out of 2 in the Human Insulin with Intra-Chain Chemical Crosslink Between Modified B27 and B30


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Insulin with Intra-Chain Chemical Crosslink Between Modified B27 and B30 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn101

b:9.5
occ:1.00
NE2 B:HIS10 2.0 9.8 1.0
NE2 F:HIS10 2.0 10.9 1.0
NE2 J:HIS10 2.1 10.2 1.0
CL B:CL102 2.2 10.6 1.0
CE1 B:HIS10 3.0 13.4 1.0
CE1 F:HIS10 3.0 14.3 1.0
CE1 J:HIS10 3.0 12.4 1.0
CD2 F:HIS10 3.0 10.3 1.0
CD2 J:HIS10 3.1 9.2 1.0
CD2 B:HIS10 3.1 9.7 1.0
ND1 B:HIS10 4.1 13.3 1.0
ND1 F:HIS10 4.1 13.2 1.0
O J:HOH235 4.1 40.9 1.0
ND1 J:HIS10 4.2 12.0 1.0
CG B:HIS10 4.2 9.5 1.0
CG F:HIS10 4.2 9.9 1.0
CG J:HIS10 4.2 9.3 1.0
O J:LEU6 4.7 10.7 1.0
O F:LEU6 4.8 12.1 1.0
CB J:LEU6 4.8 10.2 1.0
O B:LEU6 4.8 9.8 1.0
CB B:LEU6 4.8 9.8 1.0
CB F:LEU6 5.0 12.9 1.0

Zinc binding site 2 out of 2 in 5bqq

Go back to Zinc Binding Sites List in 5bqq
Zinc binding site 2 out of 2 in the Human Insulin with Intra-Chain Chemical Crosslink Between Modified B27 and B30


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human Insulin with Intra-Chain Chemical Crosslink Between Modified B27 and B30 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn101

b:9.5
occ:1.00
NE2 L:HIS10 2.0 10.5 1.0
NE2 D:HIS10 2.1 10.1 1.0
NE2 H:HIS10 2.1 10.8 1.0
CL D:CL102 2.2 10.4 1.0
CE1 D:HIS10 3.0 13.6 1.0
CE1 L:HIS10 3.0 13.3 1.0
CD2 L:HIS10 3.0 10.2 1.0
CE1 H:HIS10 3.0 12.2 1.0
CD2 H:HIS10 3.0 8.6 1.0
CD2 D:HIS10 3.1 10.2 1.0
ND1 L:HIS10 4.1 12.1 1.0
ND1 D:HIS10 4.1 13.7 1.0
ND1 H:HIS10 4.2 11.9 1.0
CG L:HIS10 4.2 9.8 1.0
CG D:HIS10 4.2 9.7 1.0
CG H:HIS10 4.2 9.0 1.0
O H:LEU6 4.7 10.5 1.0
CB H:LEU6 4.7 10.3 1.0
O D:LEU6 4.8 10.0 1.0
O L:LEU6 4.8 11.2 1.0
CB D:LEU6 4.8 10.6 1.0
O L:HOH109 5.0 30.0 1.0
CB L:LEU6 5.0 12.0 1.0

Reference:

J.Vikova, M.Collinsova, E.Kletvikova, M.Budesinsky, V.Kaplan, L.Zakova, V.Veverka, R.Hexnerova, R.J.Avino, J.Strakova, I.Selicharova, V.Vanek, D.W.Wright, C.J.Watson, J.P.Turkenburg, A.M.Brzozowski, J.Jiracek. Rational Steering of Insulin Binding Specificity By Intra-Chain Chemical Crosslinking. Sci Rep V. 6 19431 2016.
ISSN: ESSN 2045-2322
PubMed: 26792393
DOI: 10.1038/SREP19431
Page generated: Wed Dec 16 06:04:56 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy