Zinc in PDB 4zxs: Hsv-1 Nuclear Egress Complex

The structure of Hsv-1 Nuclear Egress Complex, PDB code: 4zxs was solved by J.M.Bigalke, E.E.Heldwein, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.86 / 2.77
Space group	P 6
Cell size a, b, c (Å), α, β, γ (°)	110.529, 110.529, 155.850, 90.00, 90.00, 120.00
R / Rfree (%)	21.7 / 26.5

The structure of Hsv-1 Nuclear Egress Complex also contains other interesting chemical elements:

Nickel	(Ni)	2 atoms
Chlorine	(Cl)	3 atoms
Sodium	(Na)	2 atoms

The binding sites of Zinc atom in the Hsv-1 Nuclear Egress Complex (pdb code 4zxs). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Hsv-1 Nuclear Egress Complex, PDB code: 4zxs:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Hsv-1 Nuclear Egress Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Hsv-1 Nuclear Egress Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn401 b:66.5 occ:1.00 NE2 B:HIS225 2.4 57.2 1.0 SG B:CYS125 2.6 40.6 1.0 SG B:CYS122 2.6 54.5 1.0 SG B:CYS106 2.6 46.8 1.0 CB B:CYS106 2.8 43.8 1.0 CB B:CYS122 3.1 49.4 1.0 CE1 B:HIS225 3.1 41.2 1.0 CB B:CYS125 3.5 44.0 1.0 CD2 B:HIS225 3.6 56.5 1.0 N B:CYS125 4.0 49.6 1.0 CA B:CYS125 4.2 48.7 1.0 CA B:CYS106 4.3 30.1 1.0 ND1 B:HIS225 4.3 54.4 1.0 CA B:CYS122 4.5 55.2 1.0 CG B:HIS225 4.6 44.1 1.0 O B:HOH514 4.7 47.8 1.0 CB B:ALA124 4.7 44.1 1.0 C B:ALA124 4.8 45.9 1.0 O B:LEU226 4.9 43.5 1.0 C B:CYS106 4.9 31.2 1.0

Zinc binding site 2 out of 2 in the Hsv-1 Nuclear Egress Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Hsv-1 Nuclear Egress Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn401 b:61.2 occ:1.00 NE2 D:HIS225 2.4 73.7 1.0 SG D:CYS106 2.6 56.2 1.0 SG D:CYS125 2.6 56.8 1.0 SG D:CYS122 2.6 73.4 1.0 CB D:CYS106 2.9 57.0 1.0 CE1 D:HIS225 3.0 50.7 1.0 CB D:CYS122 3.1 51.3 1.0 CB D:CYS125 3.3 55.7 1.0 CD2 D:HIS225 3.6 58.2 1.0 N D:CYS125 3.8 55.8 1.0 O D:HOH505 4.0 52.4 1.0 CA D:CYS125 4.0 56.3 1.0 ND1 D:HIS225 4.3 41.1 1.0 CA D:CYS106 4.4 43.0 1.0 CB D:ALA124 4.5 58.1 1.0 CA D:CYS122 4.6 61.1 1.0 C D:ALA124 4.6 63.4 1.0 CG D:HIS225 4.6 53.3 1.0 O D:LEU226 4.8 49.9 1.0 CA D:ALA124 5.0 57.0 1.0 C D:CYS106 5.0 41.5 1.0

J.M.Bigalke, E.E.Heldwein. Structural Basis of Membrane Budding By the Nuclear Egress Complex of Herpesviruses. Embo J. V. 34 2921 2015.
ISSN: ESSN 1460-2075
PubMed: 26511020
DOI: 10.15252/EMBJ.201592359