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Zinc in PDB 4zwi: Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with A Sulfamate-Based Inhibitor

Enzymatic activity of Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with A Sulfamate-Based Inhibitor

All present enzymatic activity of Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with A Sulfamate-Based Inhibitor:
4.2.1.1;

Protein crystallography data

The structure of Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with A Sulfamate-Based Inhibitor, PDB code: 4zwi was solved by C.L.Lomelino, B.P.Mahon, M.Mckenna, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.95 / 1.60
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.175, 41.373, 72.090, 90.00, 104.03, 90.00
R / Rfree (%) 17.9 / 22.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with A Sulfamate-Based Inhibitor (pdb code 4zwi). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with A Sulfamate-Based Inhibitor, PDB code: 4zwi:

Zinc binding site 1 out of 1 in 4zwi

Go back to Zinc Binding Sites List in 4zwi
Zinc binding site 1 out of 1 in the Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with A Sulfamate-Based Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Surface Lysine Acetylated Human Carbonic Anhydrase II in Complex with A Sulfamate-Based Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:15.7
occ:1.00
NE2 A:HIS94 2.0 16.0 1.0
NAM A:62I309 2.0 10.6 0.8
NE2 A:HIS96 2.0 13.6 1.0
ND1 A:HIS119 2.1 14.6 1.0
CD2 A:HIS94 2.9 17.1 1.0
SAL A:62I309 3.0 24.5 0.8
CE1 A:HIS119 3.0 13.3 1.0
CD2 A:HIS96 3.0 13.4 1.0
CE1 A:HIS94 3.0 14.8 1.0
CE1 A:HIS96 3.1 15.7 1.0
CG A:HIS119 3.2 10.8 1.0
CB A:HIS119 3.6 14.4 1.0
OAN A:62I309 3.7 36.5 0.8
OAO A:62I309 3.8 20.4 0.8
OG1 A:THR199 3.8 13.3 1.0
OE1 A:GLU106 4.0 14.4 1.0
OAK A:62I309 4.1 38.5 0.8
CG A:HIS94 4.1 14.9 1.0
ND1 A:HIS94 4.1 14.3 1.0
NE2 A:HIS119 4.1 12.1 1.0
ND1 A:HIS96 4.2 13.7 1.0
CG A:HIS96 4.2 14.9 1.0
CD2 A:HIS119 4.3 12.9 1.0
CAE A:62I309 4.5 37.7 0.8
O A:HOH615 4.6 49.2 1.0
CAF A:62I309 4.7 42.2 0.8
CD A:GLU106 4.9 14.9 1.0

Reference:

B.P.Mahon, C.L.Lomelino, A.L.Salguero, J.M.Driscoll, M.A.Pinard, R.Mckenna. Observed Surface Lysine Acetylation of Human Carbonic Anhydrase II Expressed in Escherichia Coli. Protein Sci. V. 24 1800 2015.
ISSN: ESSN 1469-896X
PubMed: 26266677
DOI: 10.1002/PRO.2771
Page generated: Wed Dec 16 06:00:20 2020

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