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Zinc in PDB 4ywy: Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150
Enzymatic activity of Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150
All present enzymatic activity of Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150:
2.3.2.5;
2.3.2.5;
Protein crystallography data
The structure of Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150, PDB code: 4ywy
was solved by
F.Di Pisa,
C.Pozzi,
M.Benvenuti,
S.Mangani,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 32.99 / 1.95 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 86.429, 149.540, 96.210, 90.00, 96.82, 90.00 |
| R / Rfree (%) | 16.4 / 21.1 |
Other elements in 4ywy:
The structure of Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150 also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150
(pdb code 4ywy). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150, PDB code: 4ywy:
Jump to Zinc binding site number: 1; 2; 3;
In total 3 binding sites of Zinc where determined in the Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150, PDB code: 4ywy:
Jump to Zinc binding site number: 1; 2; 3;
Zinc binding site 1 out of 3 in 4ywy
Go back to
Zinc Binding Sites List in 4ywy
Zinc binding site 1 out
of 3 in the Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150 within 5.0Å range:
|
Zinc binding site 2 out of 3 in 4ywy
Go back to
Zinc Binding Sites List in 4ywy
Zinc binding site 2 out
of 3 in the Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150 within 5.0Å range:
|
Zinc binding site 3 out of 3 in 4ywy
Go back to
Zinc Binding Sites List in 4ywy
Zinc binding site 3 out
of 3 in the Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Crystal Structure of Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with Inhibitor Pbd-150 within 5.0Å range:
|
Reference:
F.Dipisa,
C.Pozzi,
M.Benvenuti,
M.Andreini,
G.Marconi,
S.Mangani.
The Soluble Y115E-Y117E Variant of Human Glutaminyl Cyclase Is A Valid Target For X-Ray and uc(Nmr) Screening of Inhibitors Against Alzheimer Disease. Acta Crystallogr.,Sect.F V. 71 986 2015.
ISSN: ESSN 2053-230X
PubMed: 26249687
DOI: 10.1107/S2053230X15010389
Page generated: Sun Oct 27 11:29:44 2024
ISSN: ESSN 2053-230X
PubMed: 26249687
DOI: 10.1107/S2053230X15010389
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