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Zinc in PDB 4y93: Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk)

Enzymatic activity of Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk)

All present enzymatic activity of Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk):
2.7.10.2;

Protein crystallography data

The structure of Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk), PDB code: 4y93 was solved by Q.Wang, J.Kuriyan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.68 / 1.70
Space group P 2 21 21
Cell size a, b, c (Å), α, β, γ (°) 38.328, 78.647, 157.569, 90.00, 90.00, 90.00
R / Rfree (%) 15.7 / 19.5

Other elements in 4y93:

The structure of Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk) also contains other interesting chemical elements:

Calcium (Ca) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk) (pdb code 4y93). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk), PDB code: 4y93:

Zinc binding site 1 out of 1 in 4y93

Go back to Zinc Binding Sites List in 4y93
Zinc binding site 1 out of 1 in the Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the pH-Th-Kinase Construct of Bruton'S Tyrosine Kinase (Btk) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn701

b:26.4
occ:1.00
 ND1 A:HIS143 2.2 26.1 1.0
SG A:CYS165 2.3 24.6 1.0
SG A:CYS154 2.3 25.8 1.0
SG A:CYS155 2.4 26.1 1.0
HB3 A:CYS155 3.0 42.0 1.0
CE1 A:HIS143 3.0 35.1 1.0
HB3 A:CYS165 3.1 40.8 1.0
HE1 A:HIS143 3.2 42.2 1.0
HA A:HIS143 3.2 28.5 1.0
CG A:HIS143 3.2 26.6 1.0
CB A:CYS155 3.3 35.0 1.0
HB3 A:HIS143 3.3 32.4 1.0
HB2 A:CYS154 3.3 39.5 1.0
H A:CYS155 3.3 38.5 1.0
HB3 A:TYR152 3.3 41.7 1.0
CB A:CYS165 3.4 34.0 1.0
CB A:CYS154 3.5 32.9 1.0
H A:CYS165 3.5 31.8 1.0
N A:CYS155 3.6 32.1 1.0
CB A:HIS143 3.6 27.0 1.0
HD2 A:PRO144 3.7 39.3 1.0
CA A:HIS143 3.9 23.7 1.0
HB2 A:TYR152 3.9 41.7 1.0
CB A:TYR152 4.0 34.7 1.0
HB2 A:CYS165 4.0 40.8 1.0
HB2 A:CYS155 4.0 42.0 1.0
CA A:CYS155 4.1 29.3 1.0
HE21 A:GLN157 4.1 41.0 1.0
N A:CYS165 4.1 26.5 1.0
C A:CYS154 4.2 37.7 1.0
HB3 A:CYS154 4.2 39.5 1.0
NE2 A:HIS143 4.2 29.2 1.0
H A:CYS154 4.2 37.6 1.0
CA A:CYS154 4.3 30.1 1.0
HD3 A:PRO144 4.3 39.3 1.0
CD2 A:HIS143 4.3 29.8 1.0
CG A:TYR152 4.3 31.7 1.0
CA A:CYS165 4.4 34.3 1.0
CD A:PRO144 4.4 32.7 1.0
HB2 A:HIS143 4.5 32.4 1.0
HA2 A:GLY164 4.6 42.5 1.0
N A:CYS154 4.7 31.3 1.0
HA A:CYS155 4.7 35.2 1.0
CD1 A:TYR152 4.8 29.6 1.0
HD1 A:TYR152 4.8 35.6 1.0
C A:HIS143 4.8 25.4 1.0
NE2 A:GLN157 4.8 34.2 1.0
H A:CYS145 4.8 32.7 1.0
O A:HOH937 4.8 35.6 1.0
CD2 A:TYR152 4.9 29.4 1.0
N A:PRO144 4.9 25.6 1.0
O A:TYR142 4.9 25.6 1.0
N A:HIS143 4.9 23.3 1.0
HD2 A:TYR152 5.0 35.3 1.0
HE2 A:HIS143 5.0 35.1 1.0

Reference:

Q.Wang, E.M.Vogan, L.M.Nocka, C.E.Rosen, J.A.Zorn, S.C.Harrison, J.Kuriyan. Autoinhibition of Bruton'S Tyrosine Kinase (Btk) and Activation By Soluble Inositol Hexakisphosphate. Elife V. 4 2015.
ISSN: ESSN 2050-084X
PubMed: 25699547
DOI: 10.7554/ELIFE.06074
Page generated: Sun Oct 27 11:02:12 2024

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