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Atomistry » Zinc » PDB 4wnt-4x3o » 4wuy » |
Zinc in PDB 4wuy: Crystal Structure of Protein Lysine Methyltransferase SMYD2 in Complex with Lly-507, A Cell-Active, Potent and Selective InhibitorEnzymatic activity of Crystal Structure of Protein Lysine Methyltransferase SMYD2 in Complex with Lly-507, A Cell-Active, Potent and Selective Inhibitor
All present enzymatic activity of Crystal Structure of Protein Lysine Methyltransferase SMYD2 in Complex with Lly-507, A Cell-Active, Potent and Selective Inhibitor:
2.1.1.43; Protein crystallography data
The structure of Crystal Structure of Protein Lysine Methyltransferase SMYD2 in Complex with Lly-507, A Cell-Active, Potent and Selective Inhibitor, PDB code: 4wuy
was solved by
H.Nguyen,
A.Allali-Hassani,
S.Antonysamy,
S.Chang,
L.H.Chen,
C.Curtis,
S.Emtage,
L.Fan,
T.Gheyi,
F.Li,
S.Liu,
J.R.Martin,
D.Mendel,
J.B.Olsen,
L.Pelletier,
T.Shatseva,
S.Wu,
F.F.Zhang,
C.H.Arrowsmith,
P.J.Brown,
R.M.Campbell,
B.A.Garcia,
D.Barsyte-Lovejoy,
M.Mader,
M.Vedadi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Protein Lysine Methyltransferase SMYD2 in Complex with Lly-507, A Cell-Active, Potent and Selective Inhibitor
(pdb code 4wuy). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Protein Lysine Methyltransferase SMYD2 in Complex with Lly-507, A Cell-Active, Potent and Selective Inhibitor, PDB code: 4wuy: Jump to Zinc binding site number: 1; 2; 3; 4; Zinc binding site 1 out of 4 in 4wuyGo back to Zinc Binding Sites List in 4wuy
Zinc binding site 1 out
of 4 in the Crystal Structure of Protein Lysine Methyltransferase SMYD2 in Complex with Lly-507, A Cell-Active, Potent and Selective Inhibitor
Mono view Stereo pair view
Zinc binding site 2 out of 4 in 4wuyGo back to Zinc Binding Sites List in 4wuy
Zinc binding site 2 out
of 4 in the Crystal Structure of Protein Lysine Methyltransferase SMYD2 in Complex with Lly-507, A Cell-Active, Potent and Selective Inhibitor
Mono view Stereo pair view
Zinc binding site 3 out of 4 in 4wuyGo back to Zinc Binding Sites List in 4wuy
Zinc binding site 3 out
of 4 in the Crystal Structure of Protein Lysine Methyltransferase SMYD2 in Complex with Lly-507, A Cell-Active, Potent and Selective Inhibitor
Mono view Stereo pair view
Zinc binding site 4 out of 4 in 4wuyGo back to Zinc Binding Sites List in 4wuy
Zinc binding site 4 out
of 4 in the Crystal Structure of Protein Lysine Methyltransferase SMYD2 in Complex with Lly-507, A Cell-Active, Potent and Selective Inhibitor
Mono view Stereo pair view
Reference:
H.Nguyen,
A.Allali-Hassani,
S.Antonysamy,
S.Chang,
L.H.Chen,
C.Curtis,
S.Emtage,
L.Fan,
T.Gheyi,
F.Li,
S.Liu,
J.R.Martin,
D.Mendel,
J.B.Olsen,
L.Pelletier,
T.Shatseva,
S.Wu,
F.F.Zhang,
C.H.Arrowsmith,
P.J.Brown,
R.M.Campbell,
B.A.Garcia,
D.Barsyte-Lovejoy,
M.Mader,
M.Vedadi.
Lly-507, A Cell-Active, Potent and Selective Inhibitor of Protein Lysine Methyltransferase SMYD2 J.Biol.Chem. 2015.
Page generated: Sun Oct 27 10:06:44 2024
ISSN: ESSN 1083-351X DOI: 10.1074/JBC.M114.626861 |
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