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Zinc in PDB 4wsb: Bat Influenza A Polymerase with Bound Vrna Promoter

Enzymatic activity of Bat Influenza A Polymerase with Bound Vrna Promoter

All present enzymatic activity of Bat Influenza A Polymerase with Bound Vrna Promoter:
2.7.7.48;

Protein crystallography data

The structure of Bat Influenza A Polymerase with Bound Vrna Promoter, PDB code: 4wsb was solved by S.Cusack, A.Pflug, D.Guilligay, S.Reich, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.65
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 268.190, 149.320, 88.620, 90.00, 98.00, 90.00
R / Rfree (%) 21.5 / 26.7

Zinc Binding Sites:

The binding sites of Zinc atom in the Bat Influenza A Polymerase with Bound Vrna Promoter (pdb code 4wsb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Bat Influenza A Polymerase with Bound Vrna Promoter, PDB code: 4wsb:

Zinc binding site 1 out of 1 in 4wsb

Go back to Zinc Binding Sites List in 4wsb
Zinc binding site 1 out of 1 in the Bat Influenza A Polymerase with Bound Vrna Promoter


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Bat Influenza A Polymerase with Bound Vrna Promoter within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn801

b:84.8
occ:1.00
OD2 A:ASP421 3.5 60.1 1.0
OD1 A:ASP421 3.5 66.1 1.0
ND1 B:HIS562 3.5 61.5 1.0
NZ B:LYS553 3.8 84.3 1.0
CG A:ASP421 3.9 50.9 1.0
CE1 B:HIS562 4.0 66.4 1.0
CD B:LYS553 4.1 72.6 1.0
CE2 B:TYR557 4.2 78.8 1.0
CD B:ARG556 4.3 67.2 1.0
CE B:LYS553 4.5 74.7 1.0
CD2 B:TYR557 4.6 67.1 1.0
CG B:HIS562 4.7 59.9 1.0
CB B:ARG556 4.7 63.2 1.0
NH1 B:ARG556 5.0 54.0 1.0
CZ B:TYR557 5.0 80.4 1.0

Reference:

A.Pflug, D.Guilligay, S.Reich, S.Cusack. Structure of Influenza A Polymerase Bound to the Viral Rna Promoter Bound to the Viral Rna Promoter Nature.
ISSN: ESSN 1476-4687
DOI: 10.1038/NATURE14008
Page generated: Wed Dec 16 05:51:33 2020

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