Atomistry » Zinc » PDB 4ura-4uxy » 4uws
Atomistry »
  Zinc »
    PDB 4ura-4uxy »
      4uws »

Zinc in PDB 4uws: Vim-26-Peg. LEU224 in Vim-26 From Klebsiella Pneumoniae Has Implications For Drug Binding.

Protein crystallography data

The structure of Vim-26-Peg. LEU224 in Vim-26 From Klebsiella Pneumoniae Has Implications For Drug Binding., PDB code: 4uws was solved by H.-K.S.Leiros, K.S.W.Edvardsen, G.E.K.Bjerga, O.Samuelsen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 22.072 / 1.66
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 39.759, 68.172, 40.406, 90.00, 92.56, 90.00
R / Rfree (%) 15.61 / 20

Zinc Binding Sites:

The binding sites of Zinc atom in the Vim-26-Peg. LEU224 in Vim-26 From Klebsiella Pneumoniae Has Implications For Drug Binding. (pdb code 4uws). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Vim-26-Peg. LEU224 in Vim-26 From Klebsiella Pneumoniae Has Implications For Drug Binding., PDB code: 4uws:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4uws

Go back to Zinc Binding Sites List in 4uws
Zinc binding site 1 out of 2 in the Vim-26-Peg. LEU224 in Vim-26 From Klebsiella Pneumoniae Has Implications For Drug Binding.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Vim-26-Peg. LEU224 in Vim-26 From Klebsiella Pneumoniae Has Implications For Drug Binding. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1297

b:18.6
occ:1.00
ND1 B:HIS118 1.9 19.3 1.0
O B:HOH2069 2.0 18.6 1.0
NE2 B:HIS196 2.1 13.9 1.0
NE2 B:HIS116 2.1 14.2 1.0
HB2 B:HIS118 2.9 22.1 1.0
CE1 B:HIS118 2.9 15.2 1.0
CG B:HIS118 2.9 18.2 1.0
CE1 B:HIS116 2.9 14.7 1.0
CE1 B:HIS196 3.0 20.1 1.0
CD2 B:HIS196 3.1 14.3 1.0
HE1 B:HIS116 3.1 17.6 1.0
HE1 B:HIS118 3.1 18.3 1.0
CD2 B:HIS116 3.1 16.3 1.0
HE1 B:HIS196 3.2 24.1 1.0
HD2 B:HIS196 3.3 17.1 1.0
CB B:HIS118 3.3 18.4 1.0
HD2 B:HIS116 3.3 19.6 1.0
OD2 B:OCS221 3.5 15.1 0.9
HB3 B:HIS118 3.5 22.1 1.0
H11 B:PEG1299 3.5 50.0 1.0
HO1 B:PEG1299 3.7 60.4 1.0
HD2 B:OCS221 3.8 18.2 0.9
ZN B:ZN1298 3.9 9.2 0.3
NE2 B:HIS118 4.0 22.9 1.0
CD2 B:HIS118 4.0 24.6 1.0
OD1 B:ASP120 4.0 22.8 1.0
ND1 B:HIS116 4.1 14.9 1.0
O1 B:PEG1299 4.1 50.3 1.0
ND1 B:HIS196 4.1 16.8 1.0
HB2 B:OCS221 4.1 20.0 1.0
CG B:HIS196 4.2 12.0 1.0
CG B:HIS116 4.2 12.7 1.0
O B:HOH2121 4.2 33.9 1.0
C1 B:PEG1299 4.3 41.6 1.0
SG B:OCS221 4.4 20.1 1.0
OD2 B:ASP120 4.5 26.1 1.0
H B:HIS118 4.5 23.0 1.0
OD1 B:OCS221 4.6 20.7 0.7
HB3 B:OCS221 4.6 20.0 1.0
CB B:OCS221 4.6 16.7 1.0
CG B:ASP120 4.7 14.9 1.0
HD21 B:ASN233 4.7 56.0 1.0
CA B:HIS118 4.7 26.9 1.0
HE2 B:HIS118 4.8 27.5 1.0
HG2 B:ARG121 4.8 16.1 1.0
HD1 B:HIS116 4.8 17.9 1.0
H21 B:PEG1299 4.8 55.5 1.0
HD2 B:HIS118 4.9 29.6 1.0
HE B:ARG121 4.9 14.6 1.0
O B:HOH2072 4.9 29.8 1.0
HD1 B:HIS196 4.9 20.2 1.0
H12 B:PEG1299 4.9 50.0 1.0
HB3 B:SER197 4.9 17.7 1.0

Zinc binding site 2 out of 2 in 4uws

Go back to Zinc Binding Sites List in 4uws
Zinc binding site 2 out of 2 in the Vim-26-Peg. LEU224 in Vim-26 From Klebsiella Pneumoniae Has Implications For Drug Binding.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Vim-26-Peg. LEU224 in Vim-26 From Klebsiella Pneumoniae Has Implications For Drug Binding. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1298

b:9.2
occ:0.26
HD2 B:OCS221 1.1 18.2 0.9
OD2 B:OCS221 1.9 15.1 0.9
OD2 B:ASP120 1.9 26.1 1.0
O B:HOH2072 2.2 29.8 1.0
O B:HOH2069 2.2 18.6 1.0
NE2 B:HIS263 2.2 23.7 1.0
O B:HOH2121 2.3 33.9 1.0
SG B:OCS221 3.0 20.1 1.0
CG B:ASP120 3.0 14.9 1.0
CE1 B:HIS263 3.1 24.9 1.0
HE1 B:HIS263 3.2 29.8 1.0
HO1 B:PEG1299 3.2 60.4 1.0
HH21 B:ARG121 3.2 28.8 1.0
CD2 B:HIS263 3.3 27.6 1.0
OD3 B:OCS221 3.4 19.5 0.8
OD1 B:OCS221 3.4 20.7 0.7
OD1 B:ASP120 3.5 22.8 1.0
HD2 B:HIS263 3.6 33.1 1.0
HE B:ARG121 3.8 14.6 1.0
ZN B:ZN1297 3.9 18.6 1.0
HE1 B:HIS116 4.0 17.6 1.0
NH2 B:ARG121 4.0 24.0 1.0
O1 B:PEG1299 4.1 50.3 1.0
CB B:ASP120 4.2 17.8 1.0
ND1 B:HIS263 4.3 22.1 1.0
HB2 B:ASP120 4.3 21.4 1.0
HB3 B:ASP120 4.3 21.4 1.0
NE B:ARG121 4.4 12.2 1.0
CB B:OCS221 4.4 16.7 1.0
H11 B:PEG1299 4.4 50.0 1.0
CG B:HIS263 4.4 21.2 1.0
HB3 B:OCS221 4.5 20.0 1.0
HE1 B:HIS196 4.5 24.1 1.0
HH22 B:ARG121 4.6 28.8 1.0
O B:HOH2061 4.6 43.6 1.0
NE2 B:HIS196 4.7 13.9 1.0
HB2 B:OCS221 4.7 20.0 1.0
C1 B:PEG1299 4.7 41.6 1.0
H12 B:PEG1299 4.7 50.0 1.0
CZ B:ARG121 4.7 17.0 1.0
CE1 B:HIS116 4.7 14.7 1.0
CE1 B:HIS196 4.8 20.1 1.0
NE2 B:HIS116 4.9 14.2 1.0
O B:HOH2135 5.0 42.8 1.0

Reference:

H.S.Leiros, K.S.W.Edvardsen, G.E.K.Bjerga, O.Samuelsen. Structural and Biochemical Characterization of Vim-26 Show That LEU224 Has Implications For the Substrate Specificity of Vim Metallo-Beta-Lactamases. Febs J. 2015.
ISSN: ESSN 1742-4658
PubMed: 25601024
DOI: 10.1111/FEBS.13200
Page generated: Wed Dec 16 05:49:38 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy