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Atomistry » Zinc » PDB 4ufy-4upt » 4ups » |
Zinc in PDB 4ups: Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N-[3-({[(3S,5S)-5-{[(3-{[(Z)-Imino (Thiophen-2-Yl)Methyl]Amino}Benzyl)Oxy]Methyl}Pyrrolidin-3 -Yl]Oxy}Methyl)Phenyl]Thiophene-2-CarboximidamideEnzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N-[3-({[(3S,5S)-5-{[(3-{[(Z)-Imino (Thiophen-2-Yl)Methyl]Amino}Benzyl)Oxy]Methyl}Pyrrolidin-3 -Yl]Oxy}Methyl)Phenyl]Thiophene-2-Carboximidamide
All present enzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N-[3-({[(3S,5S)-5-{[(3-{[(Z)-Imino (Thiophen-2-Yl)Methyl]Amino}Benzyl)Oxy]Methyl}Pyrrolidin-3 -Yl]Oxy}Methyl)Phenyl]Thiophene-2-Carboximidamide:
1.14.13.39; Protein crystallography data
The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N-[3-({[(3S,5S)-5-{[(3-{[(Z)-Imino (Thiophen-2-Yl)Methyl]Amino}Benzyl)Oxy]Methyl}Pyrrolidin-3 -Yl]Oxy}Methyl)Phenyl]Thiophene-2-Carboximidamide, PDB code: 4ups
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4ups:
The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N-[3-({[(3S,5S)-5-{[(3-{[(Z)-Imino (Thiophen-2-Yl)Methyl]Amino}Benzyl)Oxy]Methyl}Pyrrolidin-3 -Yl]Oxy}Methyl)Phenyl]Thiophene-2-Carboximidamide also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N-[3-({[(3S,5S)-5-{[(3-{[(Z)-Imino (Thiophen-2-Yl)Methyl]Amino}Benzyl)Oxy]Methyl}Pyrrolidin-3 -Yl]Oxy}Methyl)Phenyl]Thiophene-2-Carboximidamide
(pdb code 4ups). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N-[3-({[(3S,5S)-5-{[(3-{[(Z)-Imino (Thiophen-2-Yl)Methyl]Amino}Benzyl)Oxy]Methyl}Pyrrolidin-3 -Yl]Oxy}Methyl)Phenyl]Thiophene-2-Carboximidamide, PDB code: 4ups: Zinc binding site 1 out of 1 in 4upsGo back to Zinc Binding Sites List in 4ups
Zinc binding site 1 out
of 1 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N-[3-({[(3S,5S)-5-{[(3-{[(Z)-Imino (Thiophen-2-Yl)Methyl]Amino}Benzyl)Oxy]Methyl}Pyrrolidin-3 -Yl]Oxy}Methyl)Phenyl]Thiophene-2-Carboximidamide
Mono view Stereo pair view
Reference:
Q.Jing,
H.Li,
L.J.Roman,
P.Martasek,
T.L.Poulos,
R.B.Silverman.
Combination of Chiral Linkers with Thiophenecarboximidamide Heads to Improve the Selectivity of Inhibitors of Neuronal Nitric Oxide Synthase. Bioorg.Med.Chem.Lett. V. 24 4504 2014.
Page generated: Sun Oct 27 09:15:37 2024
ISSN: ISSN 0960-894X PubMed: 25149509 DOI: 10.1016/J.BMCL.2014.07.079 |
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