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Atomistry » Zinc » PDB 4ufy-4upt » 4uh4 » |
Zinc in PDB 4uh4: Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)- 5-(Methyl(2-(Methylamino)Ethyl)Amino)BenzonitrileEnzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)- 5-(Methyl(2-(Methylamino)Ethyl)Amino)Benzonitrile
All present enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)- 5-(Methyl(2-(Methylamino)Ethyl)Amino)Benzonitrile:
1.14.13.39; Protein crystallography data
The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)- 5-(Methyl(2-(Methylamino)Ethyl)Amino)Benzonitrile, PDB code: 4uh4
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4uh4:
The structure of Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)- 5-(Methyl(2-(Methylamino)Ethyl)Amino)Benzonitrile also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)- 5-(Methyl(2-(Methylamino)Ethyl)Amino)Benzonitrile
(pdb code 4uh4). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)- 5-(Methyl(2-(Methylamino)Ethyl)Amino)Benzonitrile, PDB code: 4uh4: Zinc binding site 1 out of 1 in 4uh4Go back to Zinc Binding Sites List in 4uh4
Zinc binding site 1 out
of 1 in the Structure of Rat Neuronal Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)- 5-(Methyl(2-(Methylamino)Ethyl)Amino)Benzonitrile
Mono view Stereo pair view
Reference:
S.Kang,
H.Li,
W.Tang,
P.Martasek,
L.J.Roman,
T.L.Poulos,
R.B.Silverman.
2-Aminopyridines with A Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. J.Med.Chem. V. 58 5548 2015.
Page generated: Wed Dec 16 05:48:43 2020
ISSN: ISSN 0022-2623 PubMed: 26120733 DOI: 10.1021/ACS.JMEDCHEM.5B00573 |
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