Zinc in PDB 4tos: Crystal Structure of Tankyrase 1 with 355

All present enzymatic activity of Crystal Structure of Tankyrase 1 with 355:
2.4.2.30;

The structure of Crystal Structure of Tankyrase 1 with 355, PDB code: 4tos was solved by H.Chen, X.Zhang, L.Lum, C.Chen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.00 / 1.80
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	48.195, 81.168, 114.155, 90.00, 90.00, 90.00
R / Rfree (%)	18.1 / 21.1

The binding sites of Zinc atom in the Crystal Structure of Tankyrase 1 with 355 (pdb code 4tos). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Tankyrase 1 with 355, PDB code: 4tos:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Tankyrase 1 with 355


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Tankyrase 1 with 355 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1401 b:41.9 occ:1.00 ND1 A:HIS1237 1.9 43.0 1.0 SG A:CYS1245 2.3 41.5 1.0 SG A:CYS1242 2.4 40.9 1.0 SG A:CYS1234 2.4 36.3 1.0 CE1 A:HIS1237 2.8 41.4 1.0 CG A:HIS1237 3.1 43.6 1.0 CB A:CYS1234 3.3 33.8 1.0 CB A:CYS1242 3.3 37.4 1.0 CB A:CYS1245 3.4 35.1 1.0 CB A:HIS1237 3.6 39.2 1.0 NE2 A:HIS1237 4.0 45.4 1.0 N A:CYS1245 4.0 37.3 1.0 N A:HIS1237 4.0 41.3 1.0 CD2 A:HIS1237 4.1 47.5 1.0 CA A:CYS1245 4.3 35.9 1.0 CA A:HIS1237 4.4 42.6 1.0 O A:HOH1601 4.4 50.6 1.0 CB A:THR1236 4.6 42.4 1.0 CA A:CYS1242 4.7 38.9 1.0 CA A:CYS1234 4.7 39.0 1.0 O A:HOH1555 4.9 37.4 1.0 CB A:ILE1244 4.9 41.6 1.0 C A:THR1236 5.0 44.4 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Tankyrase 1 with 355


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Tankyrase 1 with 355 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2000 b:50.9 occ:1.00 ND1 B:HIS1237 2.0 46.5 1.0 SG B:CYS1245 2.2 46.2 1.0 SG B:CYS1242 2.4 48.0 1.0 SG B:CYS1234 2.4 49.2 1.0 CE1 B:HIS1237 2.9 47.0 1.0 CG B:HIS1237 3.1 53.8 1.0 CB B:CYS1234 3.2 50.4 1.0 CB B:CYS1245 3.3 40.5 1.0 CB B:CYS1242 3.4 44.6 1.0 CB B:HIS1237 3.5 54.6 1.0 N B:HIS1237 3.9 61.7 1.0 N B:CYS1245 4.0 40.7 1.0 NE2 B:HIS1237 4.0 54.2 1.0 CD2 B:HIS1237 4.2 59.4 1.0 CA B:CYS1245 4.3 39.4 1.0 CA B:HIS1237 4.3 59.9 1.0 CB B:THR1236 4.6 61.6 1.0 CA B:CYS1234 4.7 48.6 1.0 O B:HOH2136 4.7 40.1 1.0 CA B:CYS1242 4.8 46.6 1.0 CB B:ILE1244 4.8 43.0 1.0 C B:THR1236 4.9 59.4 1.0 N B:THR1236 4.9 54.2 1.0

O.Kulak, H.Chen, B.Holohan, X.Wu, H.He, D.Borek, Z.Otwinowski, K.Yamaguchi, L.A.Garofalo, Z.Ma, W.Wright, C.Chen, J.W.Shay, X.Zhang, L.Lum. Disruption of Wnt/ Beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Mol.Cell.Biol. 2015.
ISSN: ESSN 1098-5549
PubMed: 25939383
DOI: 10.1128/MCB.00392-15