Zinc in PDB 4tnt: Structure of the Human Mineralocorticoid Receptor in Complex with Dna

The structure of Structure of the Human Mineralocorticoid Receptor in Complex with Dna, PDB code: 4tnt was solved by W.H.Hudson, E.A.Ortlund, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.23 / 2.39
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	74.090, 115.136, 81.393, 90.00, 90.00, 90.00
R / Rfree (%)	20.9 / 25.8

The binding sites of Zinc atom in the Structure of the Human Mineralocorticoid Receptor in Complex with Dna (pdb code 4tnt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of the Human Mineralocorticoid Receptor in Complex with Dna, PDB code: 4tnt:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of the Human Mineralocorticoid Receptor in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Human Mineralocorticoid Receptor in Complex with Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn701 b:63.2 occ:1.00 SG A:CYS606 2.2 64.2 1.0 SG A:CYS603 2.3 61.1 1.0 SG A:CYS623 2.3 58.5 1.0 SG A:CYS620 2.4 66.4 1.0 CB A:CYS623 3.2 56.2 1.0 CB A:CYS603 3.3 71.2 1.0 CB A:CYS606 3.3 62.3 1.0 N A:CYS606 3.6 65.7 1.0 CB A:CYS620 3.6 66.9 1.0 N A:CYS620 3.9 66.6 1.0 CA A:CYS606 4.0 63.0 1.0 CA A:CYS620 4.3 67.1 1.0 NH1 A:ARG652 4.3 64.5 1.0 N A:CYS623 4.4 60.9 1.0 CA A:CYS623 4.4 59.9 1.0 CB A:VAL605 4.4 65.4 1.0 CB A:ASP608 4.6 73.1 1.0 C A:VAL605 4.6 66.8 1.0 N A:GLY607 4.6 66.9 1.0 C A:CYS606 4.6 63.0 1.0 CG1 A:VAL605 4.7 54.2 1.0 OG A:SER622 4.7 68.1 1.0 CA A:CYS603 4.7 70.5 1.0 NH2 A:ARG659 4.9 57.0 1.0 CA A:VAL605 4.9 63.7 1.0 N A:ASP608 4.9 70.0 1.0 C A:CYS620 5.0 70.3 1.0 N A:VAL605 5.0 62.5 1.0

Zinc binding site 2 out of 4 in the Structure of the Human Mineralocorticoid Receptor in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Human Mineralocorticoid Receptor in Complex with Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn702 b:57.2 occ:1.00 SG A:CYS639 2.3 57.3 1.0 SG A:CYS658 2.3 52.6 1.0 SG A:CYS645 2.3 52.1 1.0 SG A:CYS655 2.4 56.8 1.0 CB A:CYS639 3.2 52.4 1.0 CB A:CYS645 3.3 57.2 1.0 CB A:CYS655 3.4 49.4 1.0 CB A:CYS658 3.5 52.0 1.0 CA A:CYS639 3.9 49.2 1.0 N A:CYS645 3.9 54.3 1.0 CA A:CYS645 4.2 53.4 1.0 CA A:ASN643 4.3 55.6 1.0 N A:CYS658 4.3 49.9 1.0 N A:ASN643 4.3 62.9 1.0 CA A:CYS658 4.5 50.2 1.0 N A:ASP644 4.6 56.8 1.0 N A:ALA640 4.6 52.4 1.0 C A:ASN643 4.6 55.0 1.0 C A:CYS639 4.7 50.3 1.0 CA A:CYS655 4.8 53.0 1.0 N A:GLY641 4.8 59.3 1.0

Zinc binding site 3 out of 4 in the Structure of the Human Mineralocorticoid Receptor in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of the Human Mineralocorticoid Receptor in Complex with Dna within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn701 b:66.0 occ:1.00 SG B:CYS655 2.2 61.0 1.0 SG B:CYS645 2.2 56.1 1.0 SG B:CYS658 2.4 64.6 1.0 SG B:CYS639 2.4 68.4 1.0 CB B:CYS645 3.0 61.6 1.0 CB B:CYS655 3.3 57.3 1.0 CB B:CYS658 3.4 55.3 1.0 CB B:CYS639 3.4 59.4 1.0 N B:CYS645 3.8 67.2 1.0 O B:HOH802 4.0 54.4 1.0 CA B:CYS639 4.0 57.6 1.0 CA B:CYS645 4.1 63.8 1.0 N B:CYS658 4.2 62.9 1.0 CA B:ASN643 4.3 68.0 1.0 CA B:CYS658 4.3 56.4 1.0 N B:ASP644 4.6 71.2 1.0 N B:ASN643 4.6 68.0 1.0 C B:ASN643 4.7 67.5 1.0 CA B:CYS655 4.7 62.9 1.0 N B:ALA640 4.8 57.4 1.0 C B:CYS639 4.9 61.1 1.0 N B:GLY641 4.9 58.7 1.0 O B:HOH801 5.0 64.7 1.0

Zinc binding site 4 out of 4 in the Structure of the Human Mineralocorticoid Receptor in Complex with Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of the Human Mineralocorticoid Receptor in Complex with Dna within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn702 b:74.0 occ:1.00 SG B:CYS623 2.2 72.2 1.0 SG B:CYS603 2.3 73.5 1.0 SG B:CYS606 2.3 64.8 1.0 SG B:CYS620 2.4 74.3 1.0 CB B:CYS603 3.2 77.3 1.0 CB B:CYS606 3.2 66.5 1.0 CB B:CYS623 3.4 71.3 1.0 CB B:CYS620 3.5 78.1 1.0 N B:CYS606 3.7 69.3 1.0 CA B:CYS606 4.0 65.4 1.0 N B:CYS620 4.0 77.3 1.0 CA B:CYS620 4.3 74.0 1.0 CB B:VAL605 4.4 71.2 1.0 OG B:SER622 4.4 71.5 1.0 N B:CYS623 4.4 70.4 1.0 NH1 B:ARG652 4.5 75.2 1.0 CA B:CYS623 4.5 70.4 1.0 CB B:ASP608 4.6 74.5 1.0 C B:CYS606 4.6 68.0 1.0 C B:VAL605 4.6 74.2 1.0 CA B:CYS603 4.6 78.9 1.0 N B:GLY607 4.8 66.8 1.0 N B:ASP608 4.9 72.8 1.0 CA B:VAL605 4.9 73.7 1.0 CG1 B:VAL605 5.0 71.3 1.0 C B:CYS620 5.0 76.2 1.0

W.H.Hudson, C.Youn, E.A.Ortlund. Crystal Structure of the Mineralocorticoid Receptor Dna Binding Domain in Complex with Dna. Plos One V. 9 07000 2014.
ISSN: ESSN 1932-6203
PubMed: 25188500
DOI: 10.1371/JOURNAL.PONE.0107000