Atomistry » Zinc » PDB 4rvh-4tpg » 4tmn
Atomistry »
  Zinc »
    PDB 4rvh-4tpg »
      4tmn »

Zinc in PDB 4tmn: Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues

Enzymatic activity of Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues

All present enzymatic activity of Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues:
3.4.24.27;

Protein crystallography data

The structure of Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues, PDB code: 4tmn was solved by H.M.Holden, D.E.Tronrud, A.F.Monzingo, L.H.Weaver, B.W.Matthews, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 1.70
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 94.100, 94.100, 131.400, 90.00, 90.00, 120.00
R / Rfree (%) n/a / n/a

Other elements in 4tmn:

The structure of Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues also contains other interesting chemical elements:

Calcium (Ca) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues (pdb code 4tmn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues, PDB code: 4tmn:

Zinc binding site 1 out of 1 in 4tmn

Go back to Zinc Binding Sites List in 4tmn
Zinc binding site 1 out of 1 in the Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding. Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn322

b:12.3
occ:1.00
 OE1 E:GLU166 2.0 13.6 1.0
NE2 E:HIS142 2.1 15.7 1.0
NE2 E:HIS146 2.1 10.1 1.0
O1P E:0PK317 2.2 16.8 1.0
O2P E:0PK317 2.6 20.5 1.0
CD E:GLU166 2.8 10.4 1.0
P E:0PK317 2.9 21.7 1.0
OE2 E:GLU166 2.9 13.4 1.0
CE1 E:HIS146 3.0 7.9 1.0
CD2 E:HIS142 3.0 13.7 1.0
CE1 E:HIS142 3.1 9.3 1.0
CD2 E:HIS146 3.2 11.7 1.0
OH E:TYR157 3.7 13.2 1.0
N E:0PK317 4.1 22.5 1.0
ND1 E:HIS146 4.1 9.3 1.0
CA E:0PK317 4.2 15.6 1.0
CG E:HIS142 4.2 10.7 1.0
ND1 E:HIS142 4.2 8.6 1.0
NE2 E:HIS231 4.2 7.8 1.0
CG E:GLU166 4.2 5.6 1.0
CG E:HIS146 4.3 10.2 1.0
N1 E:0PK317 4.3 10.7 1.0
C1 E:0PK317 4.3 34.3 1.0
CA1 E:0PK317 4.4 19.6 1.0
OE1 E:GLU143 4.5 12.2 1.0
CB E:SER169 4.5 6.0 1.0
O2 E:0PK317 4.6 36.8 1.0
O1 E:0PK317 4.7 14.8 1.0
CZ E:TYR157 4.7 15.6 1.0
CD2 E:HIS231 4.8 12.3 1.0
CA E:GLU166 4.8 6.3 1.0
CE2 E:TYR157 4.8 20.1 1.0
OG E:SER169 4.8 7.9 1.0
C E:0PK317 4.9 21.3 1.0
O E:0PK317 4.9 13.7 1.0
CB E:0PK317 5.0 13.7 1.0

Reference:

H.M.Holden, D.E.Tronrud, A.F.Monzingo, L.H.Weaver, B.W.Matthews. Slow- and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding: Crystallographic Analysis of Extended Phosphonamidate Transition-State Analogues. Biochemistry V. 26 8542 1987.
ISSN: ISSN 0006-2960
PubMed: 3442675
DOI: 10.1021/BI00400A008
Page generated: Sun Oct 27 08:23:05 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy