Zinc in PDB 4rov: The Crystal Structure of Novel APOBEC3G CD2 Head-to-Tail Dimer Suggests the Binding Mode of Full-Length APOBEC3G to Hiv-1 Ssdna

The structure of The Crystal Structure of Novel APOBEC3G CD2 Head-to-Tail Dimer Suggests the Binding Mode of Full-Length APOBEC3G to Hiv-1 Ssdna, PDB code: 4rov was solved by X.Lu, T.Zhang, Z.Xu, S.Liu, B.Zhao, W.Lan, C.Wang, J.Ding, C.Cao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.20 / 1.80
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	72.402, 76.535, 80.485, 90.00, 90.00, 90.00
R / Rfree (%)	17.3 / 21.9

The binding sites of Zinc atom in the The Crystal Structure of Novel APOBEC3G CD2 Head-to-Tail Dimer Suggests the Binding Mode of Full-Length APOBEC3G to Hiv-1 Ssdna (pdb code 4rov). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the The Crystal Structure of Novel APOBEC3G CD2 Head-to-Tail Dimer Suggests the Binding Mode of Full-Length APOBEC3G to Hiv-1 Ssdna, PDB code: 4rov:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the The Crystal Structure of Novel APOBEC3G CD2 Head-to-Tail Dimer Suggests the Binding Mode of Full-Length APOBEC3G to Hiv-1 Ssdna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Crystal Structure of Novel APOBEC3G CD2 Head-to-Tail Dimer Suggests the Binding Mode of Full-Length APOBEC3G to Hiv-1 Ssdna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:25.0 occ:1.00 O A:HOH731 2.2 28.0 1.0 ND1 A:HIS257 2.2 19.7 1.0 SG A:CYS288 2.2 19.7 1.0 SG A:CYS291 2.3 19.8 1.0 CB A:CYS291 3.0 16.0 1.0 CE1 A:HIS257 3.1 21.4 1.0 CG A:HIS257 3.2 19.9 1.0 CB A:CYS288 3.3 18.9 1.0 CB A:HIS257 3.5 17.8 1.0 O A:HOH523 3.8 26.6 1.0 N A:CYS288 3.8 17.4 1.0 OE2 A:GLU259 3.8 18.3 1.0 N A:CYS291 4.0 18.8 1.0 CA A:CYS288 4.0 17.3 1.0 CA A:CYS291 4.1 17.5 1.0 O A:HOH576 4.2 31.5 1.0 NE2 A:HIS257 4.3 23.2 1.0 CD2 A:HIS257 4.3 20.6 1.0 OG A:SER290 4.5 31.9 1.0 O A:CYS288 4.5 17.1 1.0 C A:CYS288 4.5 17.9 1.0 CD A:GLU259 4.5 21.1 1.0 O A:HOH569 4.6 32.2 1.0 O A:HOH705 4.8 42.3 1.0 C A:PRO287 4.9 16.9 1.0 OE1 A:GLU259 5.0 21.5 1.0

Zinc binding site 2 out of 2 in the The Crystal Structure of Novel APOBEC3G CD2 Head-to-Tail Dimer Suggests the Binding Mode of Full-Length APOBEC3G to Hiv-1 Ssdna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Crystal Structure of Novel APOBEC3G CD2 Head-to-Tail Dimer Suggests the Binding Mode of Full-Length APOBEC3G to Hiv-1 Ssdna within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn401 b:33.0 occ:1.00 O B:HOH710 2.2 30.0 1.0 ND1 B:HIS257 2.2 33.8 1.0 SG B:CYS288 2.3 29.4 1.0 SG B:CYS291 2.3 24.6 1.0 CB B:CYS291 3.0 22.0 1.0 CE1 B:HIS257 3.1 34.6 1.0 CG B:HIS257 3.2 32.3 1.0 CB B:CYS288 3.3 26.6 1.0 CB B:HIS257 3.5 28.2 1.0 N B:CYS288 3.8 25.1 1.0 OE2 B:GLU259 3.8 21.8 1.0 O B:HOH548 3.8 32.3 1.0 O B:HOH562 4.0 39.4 1.0 CA B:CYS288 4.1 24.6 1.0 N B:CYS291 4.1 22.2 1.0 CA B:CYS291 4.1 21.6 1.0 NE2 B:HIS257 4.3 35.5 1.0 CD2 B:HIS257 4.3 36.8 1.0 CD B:GLU259 4.5 22.6 1.0 O B:CYS288 4.6 24.3 1.0 C B:CYS288 4.6 23.2 1.0 O B:HOH672 4.6 46.5 1.0 OG B:SER290 4.7 38.0 1.0 O B:HOH561 4.8 40.1 1.0 O B:HOH664 4.9 52.8 1.0 C B:PRO287 4.9 24.6 1.0 OE1 B:GLU259 4.9 25.6 1.0 O B:HOH535 5.0 27.6 1.0

X.Lu, T.Zhang, Z.Xu, S.Liu, B.Zhao, W.Lan, C.Wang, J.Ding, C.Cao. Crystal Structure of Dna Cytidine Deaminase ABOBEC3G Catalytic Domain Suggests A Binding Mode of Full-Length Enzyme to Single-Stranded Dna To Be Published.