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Atomistry » Zinc » PDB 4r5a-4rkg » 4re9 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4r5a-4rkg » 4re9 » |
Zinc in PDB 4re9: Crystal Structure of Human Insulin Degrading Enzyme (Ide) in Complex with Compound 71290Enzymatic activity of Crystal Structure of Human Insulin Degrading Enzyme (Ide) in Complex with Compound 71290
All present enzymatic activity of Crystal Structure of Human Insulin Degrading Enzyme (Ide) in Complex with Compound 71290:
3.4.24.56; Protein crystallography data
The structure of Crystal Structure of Human Insulin Degrading Enzyme (Ide) in Complex with Compound 71290, PDB code: 4re9
was solved by
W.G.Liang,
R.Deprez,
B.Deprez,
W.J.Tang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4re9:
The structure of Crystal Structure of Human Insulin Degrading Enzyme (Ide) in Complex with Compound 71290 also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Insulin Degrading Enzyme (Ide) in Complex with Compound 71290
(pdb code 4re9). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Insulin Degrading Enzyme (Ide) in Complex with Compound 71290, PDB code: 4re9: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 4re9Go back to![]() ![]()
Zinc binding site 1 out
of 2 in the Crystal Structure of Human Insulin Degrading Enzyme (Ide) in Complex with Compound 71290
![]() Mono view ![]() Stereo pair view
Zinc binding site 2 out of 2 in 4re9Go back to![]() ![]()
Zinc binding site 2 out
of 2 in the Crystal Structure of Human Insulin Degrading Enzyme (Ide) in Complex with Compound 71290
![]() Mono view ![]() Stereo pair view
Reference:
R.Deprez-Poulain,
N.Hennuyer,
D.Bosc,
W.G.Liang,
E.Enee,
X.Marechal,
J.Charton,
J.Totobenazara,
G.Berte,
J.Jahklal,
T.Verdelet,
J.Dumont,
S.Dassonneville,
E.Woitrain,
M.Gauriot,
C.Paquet,
I.Duplan,
P.Hermant,
F.X.Cantrelle,
E.Sevin,
M.Culot,
V.Landry,
A.Herledan,
C.Piveteau,
G.Lippens,
F.Leroux,
W.J.Tang,
P.Van Endert,
B.Staels,
B.Deprez.
Catalytic Site Inhibition of Insulin-Degrading Enzyme By A Small Molecule Induces Glucose Intolerance in Mice. Nat Commun V. 6 8250 2015.
Page generated: Wed Dec 16 05:45:40 2020
ISSN: ESSN 2041-1723 PubMed: 26394692 DOI: 10.1038/NCOMMS9250 |
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