Zinc in PDB 4r7y: Crystal Structure of An Active Mcm Hexamer

All present enzymatic activity of Crystal Structure of An Active Mcm Hexamer:
3.6.4.12;

The structure of Crystal Structure of An Active Mcm Hexamer, PDB code: 4r7y was solved by J.M.Miller, B.T.Arachea, L.B.Epling, E.J.Enemark, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.83 / 2.70
Space group	P 63
Cell size a, b, c (Å), α, β, γ (°)	118.902, 118.902, 199.317, 90.00, 90.00, 120.00
R / Rfree (%)	26.3 / 29.5

The structure of Crystal Structure of An Active Mcm Hexamer also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Chlorine	(Cl)	6 atoms

The binding sites of Zinc atom in the Crystal Structure of An Active Mcm Hexamer (pdb code 4r7y). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of An Active Mcm Hexamer, PDB code: 4r7y:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of An Active Mcm Hexamer


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of An Active Mcm Hexamer within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2003 b:0.7 occ:1.00 ND1 A:HIS144 2.1 0.1 1.0 SG A:CYS171 2.1 0.9 1.0 SG A:CYS149 2.2 0.2 1.0 SG A:CYS174 2.5 0.9 1.0 CB A:CYS174 2.7 0.2 1.0 CB A:CYS149 2.7 0.8 1.0 CE1 A:HIS144 3.0 0.3 1.0 CG A:HIS144 3.0 0.9 1.0 CB A:CYS171 3.1 0.7 1.0 CB A:HIS144 3.4 0.0 1.0 N A:CYS174 3.6 0.1 1.0 CA A:CYS174 3.7 0.5 1.0 NE2 A:HIS144 4.1 0.7 1.0 CD2 A:HIS144 4.1 0.3 1.0 CA A:CYS149 4.1 0.7 1.0 C A:LYS173 4.6 0.5 1.0 O A:LYS176 4.6 0.3 1.0 CA A:CYS171 4.6 0.8 1.0 CB A:LYS173 4.6 0.7 1.0 C A:CYS174 4.7 0.7 1.0 C A:CYS149 4.8 0.2 1.0 O A:HIS144 4.8 0.7 1.0 CA A:HIS144 4.9 0.8 1.0 N A:GLY175 4.9 0.7 1.0 CA A:LYS173 5.0 0.8 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of An Active Mcm Hexamer


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of An Active Mcm Hexamer within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2003 b:0.1 occ:1.00 ND1 B:HIS144 1.9 0.5 1.0 SG B:CYS171 2.3 0.9 1.0 SG B:CYS149 2.4 1.0 1.0 CB B:CYS149 2.5 0.9 1.0 SG B:CYS174 2.7 0.3 1.0 CB B:CYS174 2.7 0.6 1.0 CE1 B:HIS144 2.9 0.4 1.0 CG B:HIS144 2.9 0.4 1.0 CB B:HIS144 3.3 0.5 1.0 CB B:CYS171 3.3 0.8 1.0 N B:CYS174 3.7 0.1 1.0 CA B:CYS174 3.8 0.7 1.0 NE2 B:HIS144 4.0 0.2 1.0 CA B:CYS149 4.0 0.1 1.0 CD2 B:HIS144 4.0 0.3 1.0 O B:LYS176 4.6 0.6 1.0 CB B:LYS173 4.7 0.9 1.0 C B:LYS173 4.7 0.5 1.0 C B:CYS149 4.7 0.0 1.0 C B:CYS174 4.7 0.9 1.0 CA B:CYS171 4.8 0.4 1.0 CA B:HIS144 4.8 1.0 1.0 N B:MET150 4.9 0.7 1.0 N B:CYS149 4.9 0.1 1.0 N B:GLY175 4.9 1.0 1.0 O B:HIS144 5.0 1.0 1.0

J.M.Miller, B.T.Arachea, L.B.Epling, E.J.Enemark. Analysis of the Crystal Structure of An Active Mcm Hexamer. Elife V. 3 2014.
ISSN: ESSN 2050-084X
PubMed: 25262915
DOI: 10.7554/ELIFE.03433