Zinc in PDB 4qq4: Cw-Type Zinc Finger of MORC3 in Complex with the Amino Terminus of Histone H3

The structure of Cw-Type Zinc Finger of MORC3 in Complex with the Amino Terminus of Histone H3, PDB code: 4qq4 was solved by Y.Liu, W.Tempel, A.Dong, C.Bountra, C.H.Arrowsmith, A.M.Edwards, J.Min, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.05 / 1.75
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	62.622, 64.860, 36.015, 90.00, 90.00, 90.00
R / Rfree (%)	18 / 22.3

The structure of Cw-Type Zinc Finger of MORC3 in Complex with the Amino Terminus of Histone H3 also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Zinc atom in the Cw-Type Zinc Finger of MORC3 in Complex with the Amino Terminus of Histone H3 (pdb code 4qq4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Cw-Type Zinc Finger of MORC3 in Complex with the Amino Terminus of Histone H3, PDB code: 4qq4:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Cw-Type Zinc Finger of MORC3 in Complex with the Amino Terminus of Histone H3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cw-Type Zinc Finger of MORC3 in Complex with the Amino Terminus of Histone H3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2001 b:18.3 occ:1.00 SG A:CYS435 2.2 19.3 1.0 SG A:CYS446 2.4 18.0 1.0 SG A:CYS413 2.4 18.5 1.0 SG A:CYS416 2.4 20.2 1.0 CB A:CYS413 3.0 17.8 1.0 CB A:CYS416 3.4 18.1 1.0 CB A:CYS446 3.4 20.5 1.0 CB A:CYS435 3.4 19.3 1.0 CA A:CYS446 3.6 18.7 1.0 N A:CYS416 3.9 18.7 1.0 N A:CYS435 3.9 18.6 1.0 CA A:CYS416 4.2 19.1 1.0 N A:CYS446 4.2 15.0 1.0 CA A:CYS435 4.2 18.3 1.0 ZN A:ZN2005 4.3 18.0 1.0 CA A:CYS413 4.5 18.6 1.0 C A:ASN445 4.7 17.4 1.0 CB A:ALA415 4.8 23.1 1.0 C A:CYS446 4.8 21.3 1.0 O A:ASN445 4.9 20.6 1.0 CL A:CL2003 4.9 18.3 1.0 C A:CYS416 4.9 22.6 1.0 NH2 A:ARG420 4.9 21.7 1.0 O A:CYS446 5.0 20.0 1.0

Zinc binding site 2 out of 3 in the Cw-Type Zinc Finger of MORC3 in Complex with the Amino Terminus of Histone H3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cw-Type Zinc Finger of MORC3 in Complex with the Amino Terminus of Histone H3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2005 b:18.0 occ:1.00 CL A:CL2004 2.3 18.1 1.0 CL A:CL2003 2.3 18.3 1.0 SG B:CYS446 2.3 18.7 1.0 SG A:CYS446 2.4 18.0 1.0 CB A:CYS446 3.3 20.5 1.0 CB B:CYS446 3.4 16.5 1.0 N A:CYS446 3.8 15.0 1.0 N B:CYS446 3.9 17.2 1.0 CA A:CYS446 4.2 18.7 1.0 CA B:CYS446 4.3 16.3 1.0 ZN B:ZN2001 4.3 17.8 1.0 ZN A:ZN2001 4.3 18.3 1.0 CB B:ALA415 4.6 21.5 1.0 CB A:ALA415 4.8 23.1 1.0 C A:ASN445 4.8 17.4 1.0 C B:ASN445 4.9 16.5 1.0 CA A:ASN445 5.0 20.2 1.0

Zinc binding site 3 out of 3 in the Cw-Type Zinc Finger of MORC3 in Complex with the Amino Terminus of Histone H3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cw-Type Zinc Finger of MORC3 in Complex with the Amino Terminus of Histone H3 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn2001 b:17.8 occ:1.00 SG B:CYS416 2.3 19.1 1.0 SG B:CYS446 2.3 18.7 1.0 SG B:CYS413 2.4 17.4 1.0 SG B:CYS435 2.4 17.8 1.0 CB B:CYS413 3.0 13.8 1.0 CB B:CYS446 3.3 16.5 1.0 CB B:CYS416 3.3 19.2 1.0 CB B:CYS435 3.4 16.8 1.0 CA B:CYS446 3.5 16.3 1.0 N B:CYS416 3.7 18.2 1.0 N B:CYS435 3.9 18.9 1.0 N B:CYS446 4.1 17.2 1.0 CA B:CYS416 4.1 19.8 1.0 CA B:CYS435 4.3 17.6 1.0 ZN A:ZN2005 4.3 18.0 1.0 CA B:CYS413 4.5 15.9 1.0 C B:ASN445 4.7 16.5 1.0 CB B:ALA415 4.7 21.5 1.0 C B:CYS446 4.8 16.6 1.0 CL A:CL2004 4.8 18.1 1.0 C B:ALA415 4.9 23.7 1.0 C B:CYS416 4.9 19.0 1.0 NH2 B:ARG420 4.9 16.0 1.0 O B:ASN445 4.9 15.7 1.0

Y.Liu, W.Tempel, A.Dong, C.Bountra, C.H.Arrowsmith, A.M.Edwards, J.Min, Structural Genomics Consortium (Sgc). Cw-Type Zinc Finger of MORC3 in Complex with the Amino Terminus of Histone H3 To Be Published.