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Zinc in PDB 4q8o: Trna-Guanine Transglycosylase (Tgt) Mutant V262T in Complex with 6- Amino-2-{[2-(Morpholin-4-Yl)Ethyl]Amino}-1H,7H,8H-Imidazo[4,5- G]Quinazolin-8-One

Enzymatic activity of Trna-Guanine Transglycosylase (Tgt) Mutant V262T in Complex with 6- Amino-2-{[2-(Morpholin-4-Yl)Ethyl]Amino}-1H,7H,8H-Imidazo[4,5- G]Quinazolin-8-One

All present enzymatic activity of Trna-Guanine Transglycosylase (Tgt) Mutant V262T in Complex with 6- Amino-2-{[2-(Morpholin-4-Yl)Ethyl]Amino}-1H,7H,8H-Imidazo[4,5- G]Quinazolin-8-One:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase (Tgt) Mutant V262T in Complex with 6- Amino-2-{[2-(Morpholin-4-Yl)Ethyl]Amino}-1H,7H,8H-Imidazo[4,5- G]Quinazolin-8-One, PDB code: 4q8o was solved by M.Neeb, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 23.63 / 1.89
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 91.327, 64.858, 71.371, 90.00, 96.64, 90.00
R / Rfree (%) 15.6 / 19.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna-Guanine Transglycosylase (Tgt) Mutant V262T in Complex with 6- Amino-2-{[2-(Morpholin-4-Yl)Ethyl]Amino}-1H,7H,8H-Imidazo[4,5- G]Quinazolin-8-One (pdb code 4q8o). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase (Tgt) Mutant V262T in Complex with 6- Amino-2-{[2-(Morpholin-4-Yl)Ethyl]Amino}-1H,7H,8H-Imidazo[4,5- G]Quinazolin-8-One, PDB code: 4q8o:

Zinc binding site 1 out of 1 in 4q8o

Go back to Zinc Binding Sites List in 4q8o
Zinc binding site 1 out of 1 in the Trna-Guanine Transglycosylase (Tgt) Mutant V262T in Complex with 6- Amino-2-{[2-(Morpholin-4-Yl)Ethyl]Amino}-1H,7H,8H-Imidazo[4,5- G]Quinazolin-8-One


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna-Guanine Transglycosylase (Tgt) Mutant V262T in Complex with 6- Amino-2-{[2-(Morpholin-4-Yl)Ethyl]Amino}-1H,7H,8H-Imidazo[4,5- G]Quinazolin-8-One within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:19.1
occ:1.00
ND1 A:HIS349 2.1 17.5 1.0
SG A:CYS320 2.3 18.8 1.0
SG A:CYS318 2.3 21.6 1.0
SG A:CYS323 2.3 20.2 1.0
CE1 A:HIS349 2.9 16.6 1.0
CB A:CYS323 3.2 16.7 1.0
CB A:CYS318 3.3 23.6 1.0
CG A:HIS349 3.3 14.2 1.0
CB A:CYS320 3.3 15.8 1.0
CB A:HIS349 3.7 14.6 1.0
N A:CYS323 3.9 22.0 1.0
N A:CYS320 4.1 19.4 1.0
NE2 A:HIS349 4.1 17.4 1.0
CA A:HIS349 4.2 14.5 1.0
CA A:CYS323 4.2 22.3 1.0
CA A:CYS320 4.2 23.2 1.0
CD2 A:HIS349 4.3 15.0 1.0
CA A:CYS318 4.6 20.7 1.0
O A:HIS349 4.6 14.3 1.0
C A:CYS318 4.7 26.5 1.0
C A:CYS320 4.7 22.8 1.0
O A:CYS320 4.7 22.9 1.0
CB A:VAL322 4.8 18.3 1.0
C A:HIS349 4.8 16.6 1.0
O A:CYS318 4.9 30.3 1.0
C A:VAL322 4.9 20.1 1.0

Reference:

M.Neeb, A.Heine, G.Klebe. Creating A Resistance Model For Tgt: the Effect of Mutations on Flexible Lin-Benzoguanine Substituents To Be Published.
Page generated: Wed Dec 16 05:42:54 2020

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