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Atomistry » Zinc » PDB 4pog-4q1l » 4pzh » |
Zinc in PDB 4pzh: Crystal Structure of Human Carbonic Anhydrase Isozyme II with 2,3,5,6- Tetrafluoro-4[(2-Hydroxyethyl)Sulfonyl]BenzenesulfonamideEnzymatic activity of Crystal Structure of Human Carbonic Anhydrase Isozyme II with 2,3,5,6- Tetrafluoro-4[(2-Hydroxyethyl)Sulfonyl]Benzenesulfonamide
All present enzymatic activity of Crystal Structure of Human Carbonic Anhydrase Isozyme II with 2,3,5,6- Tetrafluoro-4[(2-Hydroxyethyl)Sulfonyl]Benzenesulfonamide:
4.2.1.1; Protein crystallography data
The structure of Crystal Structure of Human Carbonic Anhydrase Isozyme II with 2,3,5,6- Tetrafluoro-4[(2-Hydroxyethyl)Sulfonyl]Benzenesulfonamide, PDB code: 4pzh
was solved by
A.Smirnov,
E.Manakova,
S.Grazulis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4pzh:
The structure of Crystal Structure of Human Carbonic Anhydrase Isozyme II with 2,3,5,6- Tetrafluoro-4[(2-Hydroxyethyl)Sulfonyl]Benzenesulfonamide also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Carbonic Anhydrase Isozyme II with 2,3,5,6- Tetrafluoro-4[(2-Hydroxyethyl)Sulfonyl]Benzenesulfonamide
(pdb code 4pzh). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human Carbonic Anhydrase Isozyme II with 2,3,5,6- Tetrafluoro-4[(2-Hydroxyethyl)Sulfonyl]Benzenesulfonamide, PDB code: 4pzh: Zinc binding site 1 out of 1 in 4pzhGo back to Zinc Binding Sites List in 4pzh
Zinc binding site 1 out
of 1 in the Crystal Structure of Human Carbonic Anhydrase Isozyme II with 2,3,5,6- Tetrafluoro-4[(2-Hydroxyethyl)Sulfonyl]Benzenesulfonamide
Mono view Stereo pair view
Reference:
V.Dudutiene,
J.Matuliene,
A.Smirnov,
D.D.Timm,
A.Zubriene,
L.Baranauskiene,
V.Morkunaite,
J.Smirnoviene,
V.Michailoviene,
V.Juozapaitiene,
A.Mickeviciute,
J.Kazokaite,
S.Baksyte,
A.Kasiliauskaite,
J.Jachno,
J.Revuckiene,
M.Kisonaite,
V.Pilipuityte,
E.Ivanauskaite,
G.Milinaviciute,
V.Smirnovas,
V.Petrikaite,
V.Kairys,
V.Petrauskas,
P.Norvaisas,
D.Linge,
P.Gibieza,
E.Capkauskaite,
A.Zaksauskas,
E.Kazlauskas,
E.Manakova,
S.Grazulis,
J.E.Ladbury,
D.Matulis.
Discovery and Characterization of Novel Selective Inhibitors of Carbonic Anhydrase IX. J.Med.Chem. V. 57 9435 2014.
Page generated: Sun Oct 27 06:12:15 2024
ISSN: ISSN 0022-2623 PubMed: 25358084 DOI: 10.1021/JM501003K |
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