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Zinc in PDB 4pu2: Crystal Structure of Aminopeptidase N in Complex with the Phosphonic Acid Analogue of Leucine L-(R)-Leup

Enzymatic activity of Crystal Structure of Aminopeptidase N in Complex with the Phosphonic Acid Analogue of Leucine L-(R)-Leup

All present enzymatic activity of Crystal Structure of Aminopeptidase N in Complex with the Phosphonic Acid Analogue of Leucine L-(R)-Leup:
3.4.11.2;

Protein crystallography data

The structure of Crystal Structure of Aminopeptidase N in Complex with the Phosphonic Acid Analogue of Leucine L-(R)-Leup, PDB code: 4pu2 was solved by B.Nocek, S.Vassiliou, L.Berlicki, R.Mulligan, A.Mucha, A.Joachimak, Midwestcenter For Structural Genomics (Mcsg), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.89 / 2.10
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 224.328, 224.328, 57.909, 90.00, 90.00, 120.00
R / Rfree (%) 17.8 / 20.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Aminopeptidase N in Complex with the Phosphonic Acid Analogue of Leucine L-(R)-Leup (pdb code 4pu2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Aminopeptidase N in Complex with the Phosphonic Acid Analogue of Leucine L-(R)-Leup, PDB code: 4pu2:

Zinc binding site 1 out of 1 in 4pu2

Go back to Zinc Binding Sites List in 4pu2
Zinc binding site 1 out of 1 in the Crystal Structure of Aminopeptidase N in Complex with the Phosphonic Acid Analogue of Leucine L-(R)-Leup


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Aminopeptidase N in Complex with the Phosphonic Acid Analogue of Leucine L-(R)-Leup within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn904

b:23.2
occ:0.48
NE2 A:HIS297 2.0 25.5 1.0
NE2 A:HIS293 2.0 19.5 1.0
O3 A:PLU901 2.1 27.5 0.7
O1 A:PLU901 2.3 29.4 0.7
OE1 A:GLU316 2.3 28.7 1.0
P A:PLU901 2.7 28.5 0.7
HN1 A:PLU901 2.8 21.3 0.7
CD2 A:HIS297 2.9 25.0 1.0
HD2 A:HIS297 3.0 30.0 1.0
CD A:GLU316 3.0 28.6 1.0
CD2 A:HIS293 3.0 19.6 1.0
CE1 A:HIS293 3.0 19.7 1.0
CE1 A:HIS297 3.0 26.9 1.0
OE2 A:GLU316 3.0 29.6 1.0
HD2 A:HIS293 3.2 23.5 1.0
HE1 A:HIS293 3.2 23.6 1.0
HE1 A:HIS297 3.3 32.2 1.0
HE2 A:TYR377 3.5 26.8 1.0
HH A:TYR377 3.6 32.2 1.0
N A:PLU901 3.7 17.8 0.7
CA A:PLU901 3.8 20.1 0.7
O2 A:PLU901 3.9 29.2 0.7
HA A:GLU316 4.0 30.3 1.0
CG A:HIS297 4.1 25.2 1.0
HG21 A:THR319 4.1 23.5 1.0
HN2 A:PLU901 4.1 21.3 0.7
OE1 A:GLU260 4.1 21.8 1.0
ND1 A:HIS297 4.1 26.9 1.0
ND1 A:HIS293 4.1 19.9 1.0
CG A:HIS293 4.2 19.9 1.0
HB A:THR319 4.2 25.1 1.0
CE2 A:TYR377 4.3 22.4 1.0
OH A:TYR377 4.3 26.8 1.0
HA A:PLU901 4.4 24.1 0.7
OE2 A:GLU294 4.5 29.3 1.0
CG A:GLU316 4.5 27.5 1.0
HZ2 A:LYS315 4.5 21.7 1.0
CD A:GLU260 4.6 22.1 1.0
OE2 A:GLU260 4.6 23.6 1.0
OE1 A:GLU294 4.6 27.1 1.0
CZ A:TYR377 4.7 24.5 1.0
CG2 A:THR319 4.7 19.6 1.0
HG22 A:THR319 4.7 23.5 1.0
HZ3 A:LYS315 4.8 21.7 1.0
CB A:THR319 4.9 20.9 1.0
HD1 A:HIS297 4.9 32.2 1.0
HB3 A:GLU316 4.9 31.5 1.0
CA A:GLU316 4.9 25.3 1.0
HD1 A:HIS293 4.9 23.9 1.0
HB1 A:PLU901 4.9 26.8 0.7
CD A:GLU294 4.9 27.3 1.0
HG3 A:GLU316 5.0 33.0 1.0
HG2 A:GLU316 5.0 33.0 1.0
CB A:PLU901 5.0 22.3 0.7

Reference:

B.Nocek, S.Vassiliou, R.Mulligan, E.Weglarz-Tomczak, L.Berlicki, M.Pawelczak, A.Joachimiak, A.Mucha, Midwest Center For Structural Genomics (Mcsg). Crystal Structure of Aminopeptidase N in Complex with the Phosphonic Acid Analogue of Leucine To Be Published.
Page generated: Wed Dec 16 05:41:33 2020

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