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Atomistry » Zinc » PDB 4p9d-4pof » 4phw | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4p9d-4pof » 4phw » |
Zinc in PDB 4phw: Crystal Structure of PDE10A with 1H-Benzimidazol-2-Yl(4-((3- (Tetrahydro-2H-Pyran-4-Yl)-2-Pyridinyl)Oxy)Phenyl)MethanoneEnzymatic activity of Crystal Structure of PDE10A with 1H-Benzimidazol-2-Yl(4-((3- (Tetrahydro-2H-Pyran-4-Yl)-2-Pyridinyl)Oxy)Phenyl)Methanone
All present enzymatic activity of Crystal Structure of PDE10A with 1H-Benzimidazol-2-Yl(4-((3- (Tetrahydro-2H-Pyran-4-Yl)-2-Pyridinyl)Oxy)Phenyl)Methanone:
3.1.4.17; 3.1.4.35; Protein crystallography data
The structure of Crystal Structure of PDE10A with 1H-Benzimidazol-2-Yl(4-((3- (Tetrahydro-2H-Pyran-4-Yl)-2-Pyridinyl)Oxy)Phenyl)Methanone, PDB code: 4phw
was solved by
S.Chmait,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of PDE10A with 1H-Benzimidazol-2-Yl(4-((3- (Tetrahydro-2H-Pyran-4-Yl)-2-Pyridinyl)Oxy)Phenyl)Methanone
(pdb code 4phw). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of PDE10A with 1H-Benzimidazol-2-Yl(4-((3- (Tetrahydro-2H-Pyran-4-Yl)-2-Pyridinyl)Oxy)Phenyl)Methanone, PDB code: 4phw: Jump to Zinc binding site number: 1; 2; 3; 4; Zinc binding site 1 out of 4 in 4phwGo back to Zinc Binding Sites List in 4phw
Zinc binding site 1 out
of 4 in the Crystal Structure of PDE10A with 1H-Benzimidazol-2-Yl(4-((3- (Tetrahydro-2H-Pyran-4-Yl)-2-Pyridinyl)Oxy)Phenyl)Methanone
Mono view Stereo pair view
Zinc binding site 2 out of 4 in 4phwGo back to Zinc Binding Sites List in 4phw
Zinc binding site 2 out
of 4 in the Crystal Structure of PDE10A with 1H-Benzimidazol-2-Yl(4-((3- (Tetrahydro-2H-Pyran-4-Yl)-2-Pyridinyl)Oxy)Phenyl)Methanone
Mono view Stereo pair view
Zinc binding site 3 out of 4 in 4phwGo back to Zinc Binding Sites List in 4phw
Zinc binding site 3 out
of 4 in the Crystal Structure of PDE10A with 1H-Benzimidazol-2-Yl(4-((3- (Tetrahydro-2H-Pyran-4-Yl)-2-Pyridinyl)Oxy)Phenyl)Methanone
Mono view Stereo pair view
Zinc binding site 4 out of 4 in 4phwGo back to Zinc Binding Sites List in 4phw
Zinc binding site 4 out
of 4 in the Crystal Structure of PDE10A with 1H-Benzimidazol-2-Yl(4-((3- (Tetrahydro-2H-Pyran-4-Yl)-2-Pyridinyl)Oxy)Phenyl)Methanone
Mono view Stereo pair view
Reference:
E.Hu,
N.Chen,
M.P.Bourbeau,
P.E.Harrington,
K.Biswas,
R.K.Kunz,
K.L.Andrews,
S.Chmait,
X.Zhao,
C.Davis,
J.Ma,
J.Shi,
D.Lester-Zeiner,
J.Danao,
J.Able,
M.Cueva,
S.Talreja,
T.Kornecook,
H.Chen,
A.Porter,
R.Hungate,
J.Treanor,
J.R.Allen.
Discovery of Clinical Candidate 1-(4-(3-(4-(1H-Benzo[D]Imidazole-2-Carbonyl)Phenoxy) Pyrazin-2-Yl)Piperidin-1-Yl)Ethanone (Amg 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A). J.Med.Chem. V. 57 6632 2014.
Page generated: Sun Oct 27 05:52:53 2024
ISSN: ISSN 0022-2623 PubMed: 25062128 DOI: 10.1021/JM500713J |
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