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Zinc in PDB 4p65: Crystal Structure of An Cyclohexylalanine Substituted Insulin Analog.

Protein crystallography data

The structure of Crystal Structure of An Cyclohexylalanine Substituted Insulin Analog., PDB code: 4p65 was solved by V.Pandyarajan, Z.Wan, M.A.Weiss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.30 / 1.50
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 46.040, 60.900, 59.300, 90.00, 112.25, 90.00
R / Rfree (%) 16 / 20.3

Other elements in 4p65:

The structure of Crystal Structure of An Cyclohexylalanine Substituted Insulin Analog. also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of An Cyclohexylalanine Substituted Insulin Analog. (pdb code 4p65). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of An Cyclohexylalanine Substituted Insulin Analog., PDB code: 4p65:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4p65

Go back to Zinc Binding Sites List in 4p65
Zinc binding site 1 out of 2 in the Crystal Structure of An Cyclohexylalanine Substituted Insulin Analog.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of An Cyclohexylalanine Substituted Insulin Analog. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn101

b:21.0
occ:1.00
NE2 F:HIS10 2.0 18.6 1.0
NE2 B:HIS10 2.0 19.0 1.0
NE2 J:HIS10 2.0 21.1 1.0
CL B:CL102 2.2 23.0 1.0
CE1 B:HIS10 2.9 22.5 1.0
CD2 F:HIS10 3.0 21.7 1.0
CE1 F:HIS10 3.0 22.4 1.0
CD2 J:HIS10 3.0 20.1 1.0
CD2 B:HIS10 3.1 19.3 1.0
CE1 J:HIS10 3.1 22.4 1.0
HE1 B:HIS10 3.1 27.0 1.0
HD2 F:HIS10 3.1 26.1 1.0
HD2 J:HIS10 3.1 24.1 1.0
HE1 F:HIS10 3.2 26.8 1.0
HD2 B:HIS10 3.3 23.2 1.0
HE1 J:HIS10 3.3 26.9 1.0
HB3 J:LEU6 3.9 26.5 1.0
HB3 B:LEU6 3.9 26.7 1.0
HB3 F:LEU6 4.0 30.5 1.0
ND1 F:HIS10 4.1 21.6 1.0
ND1 B:HIS10 4.1 24.6 1.0
CG F:HIS10 4.1 20.9 1.0
ND1 J:HIS10 4.2 21.0 1.0
CG J:HIS10 4.2 20.1 1.0
CG B:HIS10 4.2 21.8 1.0
HD13 J:LEU6 4.5 29.9 1.0
HD13 B:LEU6 4.6 30.8 1.0
O B:LEU6 4.7 22.3 1.0
HD13 F:LEU6 4.7 34.5 1.0
HD22 F:LEU6 4.7 33.5 1.0
HD22 J:LEU6 4.8 29.1 1.0
O F:LEU6 4.8 25.8 1.0
CB J:LEU6 4.8 22.1 1.0
HD1 B:HIS10 4.8 29.5 1.0
CB B:LEU6 4.8 22.2 1.0
HD1 F:HIS10 4.8 25.9 1.0
O J:LEU6 4.9 20.5 1.0
HD22 B:LEU6 4.9 31.7 1.0
HD1 J:HIS10 4.9 25.2 1.0
CB F:LEU6 4.9 25.4 1.0

Zinc binding site 2 out of 2 in 4p65

Go back to Zinc Binding Sites List in 4p65
Zinc binding site 2 out of 2 in the Crystal Structure of An Cyclohexylalanine Substituted Insulin Analog.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of An Cyclohexylalanine Substituted Insulin Analog. within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn101

b:27.4
occ:1.00
NE2 H:HIS10 2.0 28.6 1.0
NE2 D:HIS10 2.0 24.7 1.0
NE2 L:HIS10 2.0 26.2 1.0
CL D:CL102 2.2 30.6 1.0
CD2 H:HIS10 2.9 28.2 1.0
CD2 L:HIS10 3.0 24.4 1.0
CE1 D:HIS10 3.0 25.6 1.0
CD2 D:HIS10 3.0 24.8 1.0
CE1 L:HIS10 3.0 27.6 1.0
CE1 H:HIS10 3.0 29.3 1.0
HD2 H:HIS10 3.1 33.8 1.0
HD2 L:HIS10 3.1 29.3 1.0
HD2 D:HIS10 3.2 29.7 1.0
HE1 D:HIS10 3.2 30.8 1.0
HE1 L:HIS10 3.2 33.1 1.0
HE1 H:HIS10 3.3 35.2 1.0
HB3 H:LEU6 3.8 37.6 1.0
HB3 D:LEU6 3.9 35.7 1.0
HB3 L:LEU6 4.0 38.0 1.0
ND1 D:HIS10 4.1 25.3 1.0
CG H:HIS10 4.1 27.3 1.0
ND1 L:HIS10 4.1 27.5 1.0
ND1 H:HIS10 4.1 30.7 1.0
CG L:HIS10 4.1 25.6 1.0
CG D:HIS10 4.1 24.1 1.0
HD13 H:LEU6 4.3 40.5 1.0
HD13 L:LEU6 4.7 42.8 1.0
HD13 D:LEU6 4.7 35.2 1.0
HD22 L:LEU6 4.7 41.0 1.0
CB H:LEU6 4.8 31.3 1.0
O L:LEU6 4.8 28.5 1.0
HD22 D:LEU6 4.8 37.0 1.0
O H:LEU6 4.9 33.9 1.0
CB D:LEU6 4.9 29.8 1.0
HD1 D:HIS10 4.9 30.4 1.0
HD1 L:HIS10 4.9 33.0 1.0
O D:LEU6 4.9 29.2 1.0
HD1 H:HIS10 4.9 36.8 1.0
CB L:LEU6 5.0 31.7 1.0
O D:HOH211 5.0 44.6 1.0

Reference:

V.Pandyarajan, B.J.Smith, N.B.Phillips, L.Whittaker, G.P.Cox, N.Wickramasinghe, J.G.Menting, Z.L.Wan, J.Whittaker, F.Ismail-Beigi, M.C.Lawrence, M.A.Weiss. Aromatic Anchor at An Invariant Hormone-Receptor Interface. Function of Insulin Residue B24 with Application to Protein Design. J.Biol.Chem. 2014.
ISSN: ESSN 1083-351X
PubMed: 25305014
DOI: 10.1074/JBC.M114.608562
Page generated: Wed Dec 16 05:40:11 2020

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