Atomistry » Zinc » PDB 4ow0-4p6s » 4p4e
Atomistry »
  Zinc »
    PDB 4ow0-4p6s »
      4p4e »

Zinc in PDB 4p4e: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor MP1D

Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor MP1D

All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor MP1D:
3.4.17.21;

Protein crystallography data

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor MP1D, PDB code: 4p4e was solved by C.Barinka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.29 / 1.67
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.749, 130.680, 159.522, 90.00, 90.00, 90.00
R / Rfree (%) 15.4 / 18.3

Other elements in 4p4e:

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor MP1D also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor MP1D (pdb code 4p4e). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor MP1D, PDB code: 4p4e:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4p4e

Go back to Zinc Binding Sites List in 4p4e
Zinc binding site 1 out of 2 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor MP1D


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor MP1D within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn818

b:20.6
occ:1.00
OAC A:2G4822 2.0 21.3 1.0
OD2 A:ASP387 2.0 23.2 1.0
OE2 A:GLU425 2.0 18.1 1.0
NE2 A:HIS553 2.0 17.9 1.0
OE1 A:GLU425 2.5 20.1 1.0
CD A:GLU425 2.6 19.8 1.0
CE1 A:HIS553 2.9 18.5 1.0
CG A:ASP387 3.0 21.9 1.0
PAX A:2G4822 3.0 21.0 1.0
OAF A:2G4822 3.0 20.9 1.0
CD2 A:HIS553 3.1 19.9 1.0
OD1 A:ASP387 3.4 19.7 1.0
ZN A:ZN819 3.7 21.2 1.0
CE1 A:TYR552 3.8 21.2 1.0
O A:HOH1079 3.9 22.5 1.0
OH A:TYR552 4.0 19.8 1.0
CA A:2G4822 4.1 21.4 1.0
ND1 A:HIS553 4.1 18.9 1.0
N A:2G4822 4.1 20.3 1.0
CG A:GLU425 4.1 18.6 1.0
CG A:HIS553 4.2 18.6 1.0
OAS A:2G4822 4.2 20.5 1.0
CB A:ASP387 4.3 21.8 1.0
CZ A:TYR552 4.3 19.4 1.0
C A:2G4822 4.4 22.4 1.0
OE1 A:GLU424 4.5 18.5 1.0
CD1 A:TRP381 4.5 20.1 1.0
O A:2G4822 4.5 21.7 1.0
NE1 A:TRP381 4.7 20.0 1.0
NE2 A:HIS377 4.8 19.3 1.0
CD1 A:TYR552 4.8 21.3 1.0
CE1 A:HIS377 4.8 18.5 1.0

Zinc binding site 2 out of 2 in 4p4e

Go back to Zinc Binding Sites List in 4p4e
Zinc binding site 2 out of 2 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor MP1D


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor MP1D within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn819

b:21.2
occ:1.00
OD2 A:ASP453 1.9 23.9 1.0
OAF A:2G4822 2.0 20.9 1.0
OD1 A:ASP387 2.0 19.7 1.0
NE2 A:HIS377 2.0 19.3 1.0
CG A:ASP453 2.7 23.6 1.0
OD1 A:ASP453 2.8 26.0 1.0
CG A:ASP387 3.0 21.9 1.0
CE1 A:HIS377 3.0 18.5 1.0
CD2 A:HIS377 3.0 18.5 1.0
PAX A:2G4822 3.4 21.0 1.0
OD2 A:ASP387 3.4 23.2 1.0
OE2 A:GLU425 3.7 18.1 1.0
ZN A:ZN818 3.7 20.6 1.0
OE1 A:GLU424 3.8 18.5 1.0
OAS A:2G4822 3.9 20.5 1.0
OAC A:2G4822 4.0 21.3 1.0
ND2 A:ASN519 4.1 24.4 1.0
ND1 A:HIS377 4.1 19.2 1.0
CB A:ASP453 4.1 22.1 1.0
CD A:GLU424 4.2 19.3 1.0
O A:HOH1334 4.2 53.1 1.0
CG A:HIS377 4.2 18.1 1.0
OE2 A:GLU424 4.2 21.0 1.0
CB A:ASP387 4.2 21.8 1.0
CB A:PRO388 4.4 19.3 1.0
CD A:GLU425 4.5 19.8 1.0
N A:2G4822 4.5 20.3 1.0
CA A:ASP387 4.6 20.4 1.0
CA A:PRO388 4.6 19.6 1.0
OG A:SER454 4.6 22.6 0.8
C A:ASP387 4.7 20.8 1.0
N A:PRO388 4.8 19.7 1.0
OD1 A:ASN519 4.9 25.6 1.0
O A:HOH1263 4.9 43.1 1.0
CG A:ASN519 5.0 25.3 1.0

Reference:

C.Barinka, C.Barinka. N/A N/A.
Page generated: Wed Dec 16 05:40:06 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy