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Zinc in PDB 4lqg: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor CTT1056
Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor CTT1056
All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor CTT1056:
3.4.17.21;
3.4.17.21;
Protein crystallography data
The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor CTT1056, PDB code: 4lqg
was solved by
C.Barinka,
L.Skultetyova,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 19.51 / 1.77 |
| Space group | I 2 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 101.900, 130.233, 158.252, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 15.7 / 18.2 |
Other elements in 4lqg:
The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor CTT1056 also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Calcium | (Ca) | 1 atom |
| Chlorine | (Cl) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor CTT1056
(pdb code 4lqg). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor CTT1056, PDB code: 4lqg:
Jump to Zinc binding site number: 1; 2;
In total 2 binding sites of Zinc where determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor CTT1056, PDB code: 4lqg:
Jump to Zinc binding site number: 1; 2;
Zinc binding site 1 out of 2 in 4lqg
Go back to
Zinc Binding Sites List in 4lqg
Zinc binding site 1 out
of 2 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor CTT1056
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor CTT1056 within 5.0Å range:
|
Zinc binding site 2 out of 2 in 4lqg
Go back to
Zinc Binding Sites List in 4lqg
Zinc binding site 2 out
of 2 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor CTT1056
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Phosphoramidate Inhibitor CTT1056 within 5.0Å range:
|
Reference:
S.Dannoon,
T.Ganguly,
H.Cahaya,
J.G.Geruntho,
M.R.Hopkins,
M.Regan,
J.E.Blecha,
S.Jivan,
C.Barinka,
E.F.Jones,
H.F.Vanbrocklin,
C.E.Berkman.
Structure-Activity Relationship of 18F-Labeled Phosphoramidate Peptidomimetic Psma-Targeted Inhibitor Analogues For Pet Imaging of Prostate Cancer To Be Published.
Page generated: Wed Dec 16 05:33:42 2020
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