Atomistry » Zinc » PDB 4l5u-4le6 » 4l9m
Atomistry »
  Zinc »
    PDB 4l5u-4le6 »
      4l9m »

Zinc in PDB 4l9m: Autoinhibited State of the Ras-Specific Exchange Factor RASGRP1

Protein crystallography data

The structure of Autoinhibited State of the Ras-Specific Exchange Factor RASGRP1, PDB code: 4l9m was solved by J.S.Iwig, Y.Vercoulen, R.Das, T.Barros, A.Limnander, Y.Che, J.G.Pelton, D.E.Wemmer, J.P.Roose, J.Kuriyan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.44 / 3.00
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 76.380, 76.380, 408.370, 90.00, 90.00, 120.00
R / Rfree (%) 22.4 / 26.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Autoinhibited State of the Ras-Specific Exchange Factor RASGRP1 (pdb code 4l9m). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Autoinhibited State of the Ras-Specific Exchange Factor RASGRP1, PDB code: 4l9m:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4l9m

Go back to Zinc Binding Sites List in 4l9m
Zinc binding site 1 out of 2 in the Autoinhibited State of the Ras-Specific Exchange Factor RASGRP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Autoinhibited State of the Ras-Specific Exchange Factor RASGRP1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn703

b:93.5
occ:1.00
ND1 A:HIS542 2.1 89.3 1.0
SG A:CYS572 2.1 91.7 1.0
SG A:CYS575 2.2 91.9 1.0
SG A:CYS591 2.2 0.1 1.0
CE1 A:HIS542 2.8 89.5 1.0
CG A:HIS542 3.1 89.5 1.0
CB A:CYS591 3.1 0.1 1.0
CA A:CYS591 3.4 0.3 1.0
CB A:CYS575 3.4 95.9 1.0
CB A:CYS572 3.5 87.9 1.0
O A:CYS591 3.6 0.0 1.0
CB A:HIS542 3.6 89.6 1.0
N A:CYS575 3.8 98.5 1.0
NE2 A:HIS542 3.8 89.8 1.0
CD2 A:HIS542 4.0 89.7 1.0
C A:CYS591 4.0 0.3 1.0
CA A:CYS575 4.2 96.8 1.0
CA A:HIS542 4.3 0.4 1.0
OD1 A:ASN543 4.4 0.9 1.0
N A:CYS591 4.6 0.8 1.0
CA A:CYS572 4.8 88.0 1.0
N A:ASN543 4.8 0.2 1.0
C A:ASP574 4.9 0.5 1.0
CB A:ASP574 4.9 0.5 1.0
C A:CYS575 4.9 93.1 1.0

Zinc binding site 2 out of 2 in 4l9m

Go back to Zinc Binding Sites List in 4l9m
Zinc binding site 2 out of 2 in the Autoinhibited State of the Ras-Specific Exchange Factor RASGRP1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Autoinhibited State of the Ras-Specific Exchange Factor RASGRP1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn704

b:71.9
occ:1.00
ND1 A:HIS580 2.1 76.4 1.0
SG A:CYS583 2.2 80.7 1.0
SG A:CYS558 2.3 71.8 1.0
SG A:CYS555 2.3 71.3 1.0
CB A:CYS558 2.8 73.0 1.0
CE1 A:HIS580 3.0 76.0 1.0
CG A:HIS580 3.1 77.1 1.0
CB A:CYS555 3.3 70.2 1.0
CB A:CYS583 3.4 78.8 1.0
CB A:HIS580 3.5 78.0 1.0
N A:CYS558 3.6 72.7 1.0
CA A:CYS558 3.8 72.9 1.0
N A:HIS580 3.9 72.4 1.0
NE2 A:HIS580 4.1 76.3 1.0
CD2 A:HIS580 4.2 77.0 1.0
CA A:HIS580 4.3 73.0 1.0
ND2 A:ASN557 4.5 0.4 1.0
C A:CYS558 4.6 72.2 1.0
CA A:CYS555 4.7 70.2 1.0
CA A:CYS583 4.7 75.9 1.0
CB A:ASN557 4.8 0.2 1.0
C A:ASN557 4.8 76.5 1.0
N A:CYS583 4.8 76.0 1.0
C A:CYS579 5.0 73.2 1.0
N A:ALA559 5.0 97.8 1.0

Reference:

J.S.Iwig, Y.Vercoulen, R.Das, T.Barros, A.Limnander, Y.Che, J.G.Pelton, D.E.Wemmer, J.P.Roose, J.Kuriyan. Structural Analysis of Autoinhibition in the Ras-Specific Exchange Factor RASGRP1. Elife V. 2 00813 2013.
ISSN: ESSN 2050-084X
PubMed: 23908768
DOI: 10.7554/ELIFE.00813
Page generated: Wed Dec 16 05:31:31 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy