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Zinc in PDB 4j1v: Functional and Structural Studies of MOBKL1B, A Salvador/Warts/Hippo Tumor Suppressor Pathway, in Hcv Replication

Protein crystallography data

The structure of Functional and Structural Studies of MOBKL1B, A Salvador/Warts/Hippo Tumor Suppressor Pathway, in Hcv Replication, PDB code: 4j1v was solved by H.-Y.Chung, M.Gu, C.M.Rice, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.90 / 1.95
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 50.094, 54.573, 86.574, 90.00, 89.95, 90.00
R / Rfree (%) 19.6 / 22.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Functional and Structural Studies of MOBKL1B, A Salvador/Warts/Hippo Tumor Suppressor Pathway, in Hcv Replication (pdb code 4j1v). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Functional and Structural Studies of MOBKL1B, A Salvador/Warts/Hippo Tumor Suppressor Pathway, in Hcv Replication, PDB code: 4j1v:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4j1v

Go back to Zinc Binding Sites List in 4j1v
Zinc binding site 1 out of 2 in the Functional and Structural Studies of MOBKL1B, A Salvador/Warts/Hippo Tumor Suppressor Pathway, in Hcv Replication


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Functional and Structural Studies of MOBKL1B, A Salvador/Warts/Hippo Tumor Suppressor Pathway, in Hcv Replication within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:20.8
occ:1.00
NE2 A:HIS161 2.1 16.9 1.0
NE2 A:HIS166 2.1 19.6 1.0
SG A:CYS79 2.3 17.6 1.0
SG A:CYS84 2.4 18.9 1.0
CE1 A:HIS161 3.1 17.5 1.0
CD2 A:HIS166 3.1 18.1 1.0
CD2 A:HIS161 3.1 16.5 1.0
CE1 A:HIS166 3.1 19.9 1.0
CB A:CYS79 3.2 17.6 1.0
CB A:CYS84 3.4 22.0 1.0
CA A:CYS79 3.6 22.2 1.0
CB A:ALA111 3.8 15.0 1.0
ND1 A:HIS161 4.2 15.5 1.0
ND1 A:HIS166 4.2 19.5 1.0
CG A:HIS161 4.3 16.4 1.0
CG A:HIS166 4.3 19.1 1.0
C A:CYS79 4.5 23.1 1.0
OG A:SER83 4.5 24.8 1.0
CB A:GLN165 4.6 18.7 1.0
CA A:CYS84 4.8 21.6 1.0
N A:CYS79 4.8 23.8 1.0
N A:THR80 4.9 21.7 1.0
O A:PHE78 5.0 22.7 1.0

Zinc binding site 2 out of 2 in 4j1v

Go back to Zinc Binding Sites List in 4j1v
Zinc binding site 2 out of 2 in the Functional and Structural Studies of MOBKL1B, A Salvador/Warts/Hippo Tumor Suppressor Pathway, in Hcv Replication


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Functional and Structural Studies of MOBKL1B, A Salvador/Warts/Hippo Tumor Suppressor Pathway, in Hcv Replication within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn301

b:19.7
occ:1.00
NE2 C:HIS166 2.1 18.4 1.0
NE2 C:HIS161 2.1 17.0 1.0
SG C:CYS79 2.3 19.0 1.0
SG C:CYS84 2.4 19.0 1.0
CE1 C:HIS161 3.1 18.5 1.0
CD2 C:HIS166 3.1 17.6 1.0
CE1 C:HIS166 3.1 19.3 1.0
CD2 C:HIS161 3.1 17.5 1.0
CB C:CYS79 3.2 19.5 1.0
CB C:CYS84 3.4 22.4 1.0
CA C:CYS79 3.6 22.7 1.0
CB C:ALA111 3.8 15.7 1.0
ND1 C:HIS161 4.2 16.0 1.0
ND1 C:HIS166 4.2 19.6 1.0
CG C:HIS166 4.3 19.0 1.0
CG C:HIS161 4.3 17.2 1.0
C C:CYS79 4.5 23.9 1.0
OG C:SER83 4.5 24.4 1.0
CB C:GLN165 4.6 19.8 1.0
N C:CYS79 4.8 24.0 1.0
CA C:CYS84 4.8 22.3 1.0
N C:THR80 4.9 22.5 1.0
O C:PHE78 4.9 23.6 1.0

Reference:

H.Y.Chung, M.Gu, E.Buehler, M.R.Macdonald, C.M.Rice. Seed Sequence-Matched Controls Reveal Limitations of Small Interfering Rna Knockdown in Functional and Structural Studies of Hepatitis C Virus NS5A-MOBKL1B Interaction. J.Virol. V. 88 11022 2014.
ISSN: ISSN 0022-538X
PubMed: 25031347
DOI: 10.1128/JVI.01582-14
Page generated: Wed Dec 16 05:24:52 2020

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