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Atomistry » Zinc » PDB 4i7d-4ih7 » 4ih7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Zinc » PDB 4i7d-4ih7 » 4ih7 » |
Zinc in PDB 4ih7: Hepatitis C Virus Polymerase NS5B (Bk) with Fragment-Based CompoundsEnzymatic activity of Hepatitis C Virus Polymerase NS5B (Bk) with Fragment-Based Compounds
All present enzymatic activity of Hepatitis C Virus Polymerase NS5B (Bk) with Fragment-Based Compounds:
2.7.7.48; Protein crystallography data
The structure of Hepatitis C Virus Polymerase NS5B (Bk) with Fragment-Based Compounds, PDB code: 4ih7
was solved by
S.F.Harris,
A.Wong,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Hepatitis C Virus Polymerase NS5B (Bk) with Fragment-Based Compounds
(pdb code 4ih7). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Hepatitis C Virus Polymerase NS5B (Bk) with Fragment-Based Compounds, PDB code: 4ih7: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 4ih7Go back to Zinc Binding Sites List in 4ih7
Zinc binding site 1 out
of 2 in the Hepatitis C Virus Polymerase NS5B (Bk) with Fragment-Based Compounds
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 4ih7Go back to Zinc Binding Sites List in 4ih7
Zinc binding site 2 out
of 2 in the Hepatitis C Virus Polymerase NS5B (Bk) with Fragment-Based Compounds
Mono view Stereo pair view
Reference:
F.X.Talamas,
G.Ao-Ieong,
K.A.Brameld,
E.Chin,
J.De Vicente,
J.P.Dunn,
M.Ghate,
A.M.Giannetti,
S.F.Harris,
S.S.Labadie,
V.Leveque,
J.Li,
A.S.Lui,
K.L.Mccaleb,
I.Najera,
R.C.Schoenfeld,
B.Wang,
A.Wong.
De Novo Fragment Design: A Medicinal Chemistry Approach to Fragment-Based Lead Generation. J.Med.Chem. V. 56 3115 2013.
Page generated: Sun Oct 27 00:44:19 2024
ISSN: ISSN 0022-2623 PubMed: 23509929 DOI: 10.1021/JM4002605 |
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