Zinc in PDB 4hp3: Crystal Structure of TET3 in Complex with A Cpg Dsdna

The structure of Crystal Structure of TET3 in Complex with A Cpg Dsdna, PDB code: 4hp3 was solved by X.Chao, W.Tempel, C.Bian, C.Bountra, C.H.Arrowsmith, A.M.Edwards, J.Min, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.05
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	69.892, 39.455, 54.134, 90.00, 99.92, 90.00
R / Rfree (%)	21.5 / 24.3

The binding sites of Zinc atom in the Crystal Structure of TET3 in Complex with A Cpg Dsdna (pdb code 4hp3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of TET3 in Complex with A Cpg Dsdna, PDB code: 4hp3:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of TET3 in Complex with A Cpg Dsdna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of TET3 in Complex with A Cpg Dsdna within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn201 b:32.1 occ:1.00 SG C:CYS71 2.3 35.8 1.0 SG C:CYS98 2.3 32.5 1.0 SG C:CYS68 2.3 34.8 1.0 SG C:CYS65 2.3 35.6 1.0 CB C:CYS98 3.2 31.4 1.0 CB C:CYS65 3.3 37.8 1.0 CB C:CYS71 3.4 36.7 1.0 CB C:CYS68 3.4 37.4 1.0 N C:CYS65 3.5 36.8 1.0 CA C:CYS98 3.5 29.6 1.0 N C:GLY66 3.7 35.6 1.0 CA C:CYS65 3.8 36.4 1.0 N C:CYS68 3.9 37.5 1.0 N C:GLU99 3.9 32.2 1.0 C C:CYS98 4.1 30.1 1.0 C C:CYS65 4.2 37.7 1.0 CA C:CYS68 4.2 37.1 1.0 O C:HOH304 4.3 30.8 1.0 N C:VAL67 4.4 36.8 1.0 N C:CYS71 4.4 33.5 1.0 CA C:CYS71 4.4 34.7 1.0 C C:ARG64 4.6 36.1 1.0 N C:GLN100 4.7 38.5 1.0 CA C:GLY66 4.7 37.0 1.0 CG C:GLN100 4.8 39.8 1.0 N C:CYS98 4.8 31.1 1.0 O C:CYS68 4.8 34.9 1.0 C C:CYS68 4.9 35.6 1.0 O C:HOH306 4.9 27.1 1.0 C C:GLY66 5.0 38.6 1.0 CA C:ARG64 5.0 38.9 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of TET3 in Complex with A Cpg Dsdna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of TET3 in Complex with A Cpg Dsdna within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn202 b:34.2 occ:1.00 SG C:CYS80 2.3 38.5 1.0 SG C:CYS77 2.3 39.5 1.0 SG C:CYS83 2.3 39.5 1.0 SG C:CYS93 2.4 32.5 1.0 CB C:CYS93 3.3 33.1 1.0 CB C:CYS80 3.4 38.3 1.0 CB C:CYS77 3.4 42.7 1.0 CB C:CYS83 3.4 46.1 1.0 N C:CYS77 3.6 43.1 1.0 N C:GLY78 3.7 41.2 1.0 CA C:CYS93 3.7 31.5 1.0 N C:CYS80 3.8 37.7 1.0 CA C:CYS77 3.9 43.0 1.0 N C:LYS94 4.0 32.7 1.0 CA C:CYS80 4.2 38.1 1.0 C C:CYS77 4.2 44.5 1.0 N C:CYS83 4.2 43.4 1.0 C C:CYS93 4.3 31.0 1.0 N C:ALA79 4.3 41.6 1.0 CA C:CYS83 4.4 45.0 1.0 CA C:GLY78 4.7 43.5 1.0 N C:MET95 4.7 32.0 1.0 C C:PRO76 4.7 44.3 1.0 C C:CYS80 4.8 38.7 1.0 C C:GLY78 4.9 43.9 1.0 O C:CYS80 4.9 37.4 1.0 C C:ALA79 4.9 39.9 1.0 CG C:MET95 4.9 38.5 1.0 NH1 C:ARG86 5.0 44.8 0.5

Y.Xu, C.Xu, A.Kato, W.Tempel, J.G.Abreu, C.Bian, Y.Hu, D.Hu, B.Zhao, T.Cerovina, J.Diao, F.Wu, H.H.He, Q.Cui, E.Clark, C.Ma, A.Barbara, G.J.Veenstra, G.Xu, U.B.Kaiser, X.S.Liu, S.P.Sugrue, X.He, J.Min, Y.Kato, Y.G.Shi. TET3 Cxxc Domain and Dioxygenase Activity Cooperatively Regulate Key Genes For Xenopus Eye and Neural Development. Cell(Cambridge,Mass.) V. 151 1200 2012.
ISSN: ISSN 0092-8674
PubMed: 23217707
DOI: 10.1016/J.CELL.2012.11.014