Zinc in PDB 4hd8: Crystal Structure of Human SIRT3 in Complex with Fluor-De-Lys Peptide and Piceatannol

The structure of Crystal Structure of Human SIRT3 in Complex with Fluor-De-Lys Peptide and Piceatannol, PDB code: 4hd8 was solved by G.T.T.Nguyen, M.Gertz, C.Steegborn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.74 / 2.30
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	114.600, 114.600, 123.700, 90.00, 90.00, 120.00
R / Rfree (%)	17.4 / 24

The binding sites of Zinc atom in the Crystal Structure of Human SIRT3 in Complex with Fluor-De-Lys Peptide and Piceatannol (pdb code 4hd8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human SIRT3 in Complex with Fluor-De-Lys Peptide and Piceatannol, PDB code: 4hd8:

Zinc binding site 1 out of 1 in the Crystal Structure of Human SIRT3 in Complex with Fluor-De-Lys Peptide and Piceatannol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human SIRT3 in Complex with Fluor-De-Lys Peptide and Piceatannol within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:21.8 occ:1.00 SG A:CYS259 2.3 19.6 1.0 SG A:CYS280 2.3 20.7 1.0 SG A:CYS283 2.3 19.3 1.0 SG A:CYS256 2.4 17.6 1.0 CB A:CYS280 3.0 20.0 1.0 CB A:CYS256 3.2 18.7 1.0 CB A:CYS259 3.3 21.9 1.0 CB A:CYS283 3.5 20.8 1.0 N A:CYS259 3.6 21.9 1.0 N A:CYS283 3.9 24.0 1.0 CA A:CYS259 4.0 21.8 1.0 CA A:CYS283 4.2 21.5 1.0 CA A:CYS280 4.4 22.4 1.0 N A:GLY285 4.6 21.1 1.0 CA A:CYS256 4.6 18.6 1.0 NH2 A:ARG261 4.7 17.8 1.0 C A:CYS259 4.7 23.0 1.0 C A:VAL258 4.8 24.1 1.0 C A:CYS283 4.8 22.0 1.0 CB A:VAL258 4.8 24.0 1.0 CA A:GLY285 4.9 19.2 1.0 N A:THR284 4.9 20.7 1.0 N A:GLN260 5.0 24.3 1.0 CD A:ARG261 5.0 21.8 1.0

M.Gertz, G.T.Nguyen, F.Fischer, B.Suenkel, C.Schlicker, B.Franzel, J.Tomaschewski, F.Aladini, C.Becker, D.Wolters, C.Steegborn. A Molecular Mechanism For Direct Sirtuin Activation By Resveratrol. Plos One V. 7 49761 2012.
ISSN: ESSN 1932-6203
PubMed: 23185430
DOI: 10.1371/JOURNAL.PONE.0049761