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Atomistry » Zinc » PDB 4ggg-4gsk » 4gsc » |
Zinc in PDB 4gsc: Structure Analysis of Insulin Degrading Enzyme with Compound BDM41559 ((S)-2-[2-(Carboxymethyl-Phenethyl-Amino)-Acetylamino]-3-(1H- Imidazol-4-Yl)-Propionic Acid Methyl Ester)Enzymatic activity of Structure Analysis of Insulin Degrading Enzyme with Compound BDM41559 ((S)-2-[2-(Carboxymethyl-Phenethyl-Amino)-Acetylamino]-3-(1H- Imidazol-4-Yl)-Propionic Acid Methyl Ester)
All present enzymatic activity of Structure Analysis of Insulin Degrading Enzyme with Compound BDM41559 ((S)-2-[2-(Carboxymethyl-Phenethyl-Amino)-Acetylamino]-3-(1H- Imidazol-4-Yl)-Propionic Acid Methyl Ester):
3.4.24.56; Protein crystallography data
The structure of Structure Analysis of Insulin Degrading Enzyme with Compound BDM41559 ((S)-2-[2-(Carboxymethyl-Phenethyl-Amino)-Acetylamino]-3-(1H- Imidazol-4-Yl)-Propionic Acid Methyl Ester), PDB code: 4gsc
was solved by
Q.Guo,
R.Deprez-Poulain,
B.Deprez,
W.J.Tang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure Analysis of Insulin Degrading Enzyme with Compound BDM41559 ((S)-2-[2-(Carboxymethyl-Phenethyl-Amino)-Acetylamino]-3-(1H- Imidazol-4-Yl)-Propionic Acid Methyl Ester)
(pdb code 4gsc). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure Analysis of Insulin Degrading Enzyme with Compound BDM41559 ((S)-2-[2-(Carboxymethyl-Phenethyl-Amino)-Acetylamino]-3-(1H- Imidazol-4-Yl)-Propionic Acid Methyl Ester), PDB code: 4gsc: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 4gscGo back to Zinc Binding Sites List in 4gsc
Zinc binding site 1 out
of 2 in the Structure Analysis of Insulin Degrading Enzyme with Compound BDM41559 ((S)-2-[2-(Carboxymethyl-Phenethyl-Amino)-Acetylamino]-3-(1H- Imidazol-4-Yl)-Propionic Acid Methyl Ester)
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 4gscGo back to Zinc Binding Sites List in 4gsc
Zinc binding site 2 out
of 2 in the Structure Analysis of Insulin Degrading Enzyme with Compound BDM41559 ((S)-2-[2-(Carboxymethyl-Phenethyl-Amino)-Acetylamino]-3-(1H- Imidazol-4-Yl)-Propionic Acid Methyl Ester)
Mono view Stereo pair view
Reference:
J.Charton,
M.Gauriot,
Q.Guo,
N.Hennuyer,
X.Marechal,
J.Dumont,
M.Hamdane,
V.Pottiez,
V.Landry,
O.Sperandio,
M.Flipo,
L.Buee,
B.Staels,
F.Leroux,
W.J.Tang,
B.Deprez,
R.Deprez-Poulain.
Imidazole-Derived 2-[N-Carbamoylmethyl-Alkylamino]Acetic Acids, Substrate-Dependent Modulators of Insulin-Degrading Enzyme in Amyloid-Beta Hydrolysis. Eur.J.Med.Chem. V. 79 184 2014.
Page generated: Sat Oct 26 23:29:01 2024
ISSN: ISSN 0223-5234 PubMed: 24735644 DOI: 10.1016/J.EJMECH.2014.04.009 |
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