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Atomistry » Zinc » PDB 4gfj-4gsc » 4gr3 » |
Zinc in PDB 4gr3: Crystal Structure of the Catalytic Domain of Human MMP12 in Complex with Selective Phosphinic Inhibitor RXP470AEnzymatic activity of Crystal Structure of the Catalytic Domain of Human MMP12 in Complex with Selective Phosphinic Inhibitor RXP470A
All present enzymatic activity of Crystal Structure of the Catalytic Domain of Human MMP12 in Complex with Selective Phosphinic Inhibitor RXP470A:
3.4.24.65; Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of Human MMP12 in Complex with Selective Phosphinic Inhibitor RXP470A, PDB code: 4gr3
was solved by
E.A.Stura,
L.Vera,
F.Beau,
L.Devel,
E.Cassar-Lajeunesse,
V.Dive,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4gr3:
The structure of Crystal Structure of the Catalytic Domain of Human MMP12 in Complex with Selective Phosphinic Inhibitor RXP470A also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of the Catalytic Domain of Human MMP12 in Complex with Selective Phosphinic Inhibitor RXP470A
(pdb code 4gr3). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Catalytic Domain of Human MMP12 in Complex with Selective Phosphinic Inhibitor RXP470A, PDB code: 4gr3: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 4gr3Go back to![]() ![]()
Zinc binding site 1 out
of 2 in the Crystal Structure of the Catalytic Domain of Human MMP12 in Complex with Selective Phosphinic Inhibitor RXP470A
![]() Mono view ![]() Stereo pair view
Zinc binding site 2 out of 2 in 4gr3Go back to![]() ![]()
Zinc binding site 2 out
of 2 in the Crystal Structure of the Catalytic Domain of Human MMP12 in Complex with Selective Phosphinic Inhibitor RXP470A
![]() Mono view ![]() Stereo pair view
Reference:
B.Czarny,
E.A.Stura,
L.Devel,
L.Vera,
E.Cassar-Lajeunesse,
F.Beau,
V.Calderone,
M.Fragai,
C.Luchinat,
V.Dive.
Molecular Determinants of A Selective Matrix Metalloprotease-12 Inhibitor: Insights From Crystallography and Thermodynamic Studies. J.Med.Chem. V. 56 1149 2013.
Page generated: Wed Dec 16 05:20:21 2020
ISSN: ISSN 0022-2623 PubMed: 23343195 DOI: 10.1021/JM301574D |
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