Zinc in PDB 4gi4: Trna Guanine Transglycosylase in Complex with Disubstituted Lin- Benzoguanine Inhibitor

All present enzymatic activity of Trna Guanine Transglycosylase in Complex with Disubstituted Lin- Benzoguanine Inhibitor:
2.4.2.29;

The structure of Trna Guanine Transglycosylase in Complex with Disubstituted Lin- Benzoguanine Inhibitor, PDB code: 4gi4 was solved by F.Immekus, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.97
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	89.850, 64.728, 70.650, 90.00, 96.05, 90.00
R / Rfree (%)	19 / 24.8

The binding sites of Zinc atom in the Trna Guanine Transglycosylase in Complex with Disubstituted Lin- Benzoguanine Inhibitor (pdb code 4gi4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna Guanine Transglycosylase in Complex with Disubstituted Lin- Benzoguanine Inhibitor, PDB code: 4gi4:

Zinc binding site 1 out of 1 in the Trna Guanine Transglycosylase in Complex with Disubstituted Lin- Benzoguanine Inhibitor


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna Guanine Transglycosylase in Complex with Disubstituted Lin- Benzoguanine Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn502 b:16.7 occ:1.00 ND1 A:HIS349 2.1 15.8 1.0 SG A:CYS323 2.3 19.6 1.0 SG A:CYS318 2.3 20.9 1.0 SG A:CYS320 2.4 15.7 1.0 CE1 A:HIS349 2.9 20.3 1.0 CB A:CYS323 3.2 13.8 1.0 CB A:CYS318 3.2 17.2 1.0 CG A:HIS349 3.3 15.5 1.0 CB A:CYS320 3.5 14.2 1.0 CB A:HIS349 3.8 13.9 1.0 N A:CYS323 4.0 13.4 1.0 NE2 A:HIS349 4.1 15.4 1.0 N A:CYS320 4.1 22.9 1.0 CA A:HIS349 4.1 12.5 1.0 CA A:CYS323 4.2 15.1 1.0 CA A:CYS320 4.3 16.0 1.0 CD2 A:HIS349 4.3 14.7 1.0 CA A:CYS318 4.5 20.6 1.0 O A:HIS349 4.5 13.0 1.0 O A:CYS320 4.6 14.8 1.0 C A:CYS318 4.6 22.5 1.0 C A:CYS320 4.7 13.6 1.0 CB A:VAL322 4.8 16.6 1.0 C A:HIS349 4.8 17.2 1.0 O A:CYS318 4.8 23.2 1.0

F.Immekus, L.J.Barandun, F.Diederich, G.Klebe. Two-Armed Benzopurine Inhibitors of Tgt To Be Published.